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Obesity gene atlas in mammals
Kunej, Tanja (Author), Jevšinek Skok, Daša (Author), Zorc, Minja (Author), Ogrinc, Ana (Author), Michal, Jennifer J. (Author), Kovač, Milena (Author), Jiang, Zhihua (Author)

URLURL - Presentation file, Visit http://www.jgenomics.com/v01p0045.pdf This link opens in a new window

Abstract
Obesity in humans has increased at an alarming rate over the past two decades and has become one of the leading public health problems worldwide. Studies have revealed a large number of genes/markers that are associated with obesity and/or obesity-related phenotypes, indicating an urgent need to develop a central database for helping the community understand the genetic complexity of obesity. In the present study, we collected a total of 1.736 obesity associated loci and created a freely available obesity database, including 1,515 protein-coding genes and 221 microRNAs (miRNA) collected from four mammalian species: human, cattle, rat and mouse. These loci were integrated as orthologs on comparative genomic views in human, cattle, and mouse. The database and genomic views are freely available online at: http://www.integratomics-time.com/fat_deposition. Bioinformatics analyses of the collected data revealed some potential novel obesity related molecular markers which represent focal points for testing more targeted hypotheses and designing experiments for further studies. We belive that this centralized database on obesity and adipogenesis will facilitate development of comparative systems biology approaches to address this important health issue in human and their potential applications in animals.

Language:English
Keywords:molekularna genetika, baze podatkov, geni, debelost, sesalci
Work type:Not categorized (r6)
Tipology:1.01 - Original Scientific Article
Organization:BF - Biotechnical Faculty
Year:2013
Number of pages:str. 45-55
Numbering:Vol. 1
UDC:575
COBISS.SI-ID:3014280 Link is opened in a new window
Views:905
Downloads:996
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