Polimorfizmi v genih, vključenih v vstop SARS-CoV-2 v celico, so povezani s težjim potekom bolezni covid-19 : analiza polimorfizmov v genih ACE1, ACE2 in TMPRSS2 v slovenski kohorti : raziskovalni podatki, obravnavani v članku

Štampar, Patricija (author), Blagus, Tanja (author), Vogrinc, David (author), Bogovič, Petra (author), Turel, Gabriele (author), Strle, Franc (author), Petek Šter, Marija (author), Kolšek Šušteršič, Maja (author), Dolžan, Vita (author)

Raziskava je proučevala povezavo med genetskimi različicami v genih, ki sodelujejo pri vstopu virusa SARS-CoV-2 v gostiteljsko celico, in težo bolezni covid-19 v slovenski populaciji. Vključenih je bilo 240 odraslih bolnikov z različno težkim potekom bolezni covida-19. Analizirani so bili izbrani polimorfizmi v genih ACE1, ACE2 in TMPRSS2, njihova povezanost s kliničnimi značilnostmi bolezni pa je bila ovrednotena z univariatnimi in multivariatnimi statističnimi modeli. Polimorfizem TMPRSS2 rs12329760 je bil povezan z blažjim potekom bolezni, medtem ko so bile posamezne različice v genih ACE1 in ACE2 povezane s trajanjem hospitalizacije in drugimi kazalniki težjega poteka bolezni. Rezultati kažejo, da lahko genetska variabilnost v poteh vstopa virusa prispeva k razlikam v kliničnem poteku covida-19. Podatkovna zbirka vsebuje psevdonimizirane demografske in genotipske podatke preiskovancev. Zaradi varovanja osebnih podatkov je dostop do zbirke omejen in je mogoč le na podlagi utemeljene zahteve ter po odobritvi skrbnika podatkov.

• Language: Slovenian
• Keywords: teža bolezni covid-19, TMPRSS2, ACE1, ACE2, genetika gostitelja, polimorfizmi posameznega nukleotida (SNP), genetska asociacijska raziskava
• Typology: 2.20 - Research data
• Geographic coverage: Slovenija / Slovenia
• Temporal coverage: Od septembra 2020 do decembra 2021 / From September 2020 to December 2021
• Organization: MF - Faculty of Medicine
• Year: 2026
• PID: 20.500.12556/RUL-188382
• Data col. methods: Measurements and tests
• Publication date in RUL: 29.09.2026

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: English
• Title: Polymorphisms in SARS-CoV-2 entry pathway genes are associated with COVID-19 severity : analysis of ACE1, ACE2, and TMPRSS2 polymorphisms in a Slovenian cohort : research data underlying the article

Abstract

The study investigated the association between genetic polymorphisms in genes involved in SARS-CoV-2 entry into host cells and COVID-19 severity in the Slovenian population. The study included 240 adult patients with varying degrees of COVID-19 severity. Selected polymorphisms in the ACE1, ACE2, and TMPRSS2 genes were analysed, and their associations with the clinical characteristics of the disease were evaluated using univariate and multivariate statistical models. The TMPRSS2 rs12329760 polymorphism was associated with a milder disease, whereas polymorphisms in the ACE1 and ACE2 genes were associated with the duration of hospitalisation and other indicators of severe disease. The results suggest that genetic variability in viral entry pathways may contribute to differences in the clinical course and outcome of COVID-19. The dataset contains pseudonymised demographic and genotype data from the study participants. To protect personal data, access to the dataset is restricted and is granted only upon a justified request and with the approval of the data custodian.

• Keywords: COVID-19 severity, TMPRSS2, ACE1, ACE2, host genetics, single nucleotide polymorphisms, genetic association study

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0170
• Name: Molekulski mehanizmi uravnavanja celičnih procesov v povezavi z nekaterimi boleznimi pri človeku