Vpliv obrokov z veliko vsebnostjo maščob na obnašanje laboratorijskih miši : diplomsko delo

Škruba, Katja (author), Pirman, Tatjana (mentor)

Namen diplomskega dela je, da bi spoznali vpliv zahodnjaškega načina prehranjevanja na obnašanje laboratorijskih miši. Opravili smo pregled raziskav, povezanih z vplivom obrokov z veliko vsebnostjo maščob na splošno stanje laboratorijskih miši, ter kako to vpliva na njihovo obnašanje. Preučili smo učinke zahodnjaškega načina prehranjevanja na telo in na obnašanje in ugotovili, da je bilo na tem področju opravljenih veliko raziskav, ki dokazujejo, da zahodnjaški način prehranjevanja predvsem negativno vpliva na hipokampus, ki je ključen za učenje, spomin in uravnavanje razpoloženja. Pregledali smo teste obnašanja, ki se navadno uporabljajo in literaturo o inovativnih rešitvah, dodatkih v obrokih, ki zmanjšujejo učinke zahodnjaške prehrane, ter ugotovili, da so bili najboljši rezultati ob uporabi rožmarinske kisline in izvlečka zelenega čaja. Izvedeli smo, da je odziv na nezdrave obroke odvisen od genov, spola in starosti miši. Zahodnjaški način prehranjevanja spodbuja obnašanja, podobna avtizmu ter motnji pozornosti s hiperaktivnostjo. Zahodnjaški način prehranjevanja pri miših povzroči hitrejši razvoj Parkinsonove bolezni, pojavijo pa se tudi kronična sistemska vnetja in oksidativni stres, kar poškoduje krvno-možgansko pregrado. Ugotovili smo tudi, da ravno pomanjkanje mikrohranil v zahodnjaškem načinu prehranjevanja pomembno moderira obnašanje živali.

• Language: Slovenian
• Keywords: laboratorijske miši, testi obnašanja, zahodnjaški način prehranjevanja, debelost, depresija, diplomska dela
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Place of publishing: Ljubljana
• Publisher: K. Škruba
• Year: 2026
• Number of pages: 1 spletni vir (1 datoteka PDF (VII, [15] str.))
• PID: 20.500.12556/RUL-188042
• UDC: 636.084/.087(043.2)
• COBISS.SI-ID: 291574019
• Publication date in RUL: 18.09.2026

Secondary language

• Language: English
• Title: The effect of a high fat diet on changes in behavior of laboratory mice : B. Sc. thesis

Abstract

The purpose of this thesis is to understand the impact of Western diet on behaviour of laboratory mice. We conducted a review of studies related to the influence of a high-fat diet on the general condition of laboratory mice and how this affects their behaviour. We examined the effects of a Western diet on the body and behaviour and found that many studies have been conducted in this field, demonstrating that the Western diet has predominantly negative effects on the hippocampus, which is crucial for learning, memory, and mood regulation. We reviewed behavioural tests that are commonly used and the literature on innovative solutions and feed additives that reduce the effects of the Western diet, and found that the best results were achieved with the use of rosmarinic acid and green tea extract. We learned that the response to an unhealthy diet depends on the genes, sex, and age of the mice. The Western diet promotes autism-like behaviours and behaviours similar to those associated with attention-deficit/hyperactivity disorder. A Western diet accelerates the development of Parkinson's disease in mice and leads to chronic systemic inflammation and oxidative stress, which damage the blood-brain barrier. We also found that the lack of micronutrients in the Western diet significantly modulates the animals' behaviour.

• Keywords: laboratory mice, behavioral tests, Western diet, obesity, depression