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Analiza procesa filmskega oblaganja delno obložene tablete
ID Novak, Žiga (Author), ID Golobič, Iztok (Mentor) More about this mentor... This link opens in a new window, ID Može, Matic (Comentor)

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Abstract
Filmsko oblaganje tablet predstavlja poglavitno dejavnost farmacevtskih družb za izboljšanje lastnosti tablet, kot so učinkovitost dostave učinkovin, odstranjevanje neprijetnega vonja, okusa ter izboljšave stabilnosti učinkovin. V nalogi smo s pomočjo eksperimentalne proge, ki je vključevala mizico za postavitev tablete ter dozirnik kapljic, izvedli študijo kapljičastega pronicanja učinkovine v tableto. V posebni komori smo simulirali pogoje iz farmacevtskih oblagalnikov ter izvedli meritve omočene površine, širine in globine pronicanja, kontaktnega kota kapljice ob stiku s površino, analizo hrapavosti površin ter debeline obloge. Obravnavali smo vpliv debeline posamezne nanešene obloge na pronicanje kapljice v tableto in širjenje kapljice po površini.

Language:Slovenian
Keywords:proces, filmsko oblaganje, tableta, kapljičasto nanašanje, delno obložene tablete
Work type:Master's thesis/paper
Organization:FS - Faculty of Mechanical Engineering
Year:2026
PID:20.500.12556/RUL-187480 This link opens in a new window
Publication date in RUL:11.09.2026
Views:34
Downloads:12
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Secondary language

Language:English
Title:Process analysis of film coating of a partially coated tablet
Abstract:
Film coating of tablets is an important process in the pharmaceutical industry for improving tablet properties, such as the efficiency of drug delivery, masking unpleasant odours and tastes, and enhancing drug stability. In this thesis, an experimental setup consisting of a tablet positioning stage and a droplet dispenser was used to investigate the penetration of a drug solution into tablets. In a separate experimental chamber, conditions encountered in pharmaceutical coating equipment were simulated, and measurements of the wetted surface area, penetration width and depth, droplet contact angle upon contact with the surface, surface roughness, and coating thickness were performed. The influence of coating thickness on liquid penetration into the tablet and droplet spreading over the surface was investigated.

Keywords:process, film coating, tablet, droplet application, partially coated tablets

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