Incorporation of the trifluoromethylthio group ($CF_3S−$) into biomolecules : a versatile tool for advancing life sciences

Gregorc, Jure (author), Lensen, Nathalie (author), Chaume, Grégory (author), Iskra, Jernej (author), Brigaud, Thierry (author)

The trifluoromethylthio functional group (CF$_3$S-) has gained considerable attention in synthetic and medicinal chemistry due to its ability to enhance the pharmacokinetic profiles of functionalized compounds. This Synopsis highlights recent progress in the incorporation of the CF$_3$S group into biomolecules and bioactive compounds, with a focus on its influence on physicochemical properties and its applications in medicinal chemistry and chemical biology.

• Language: English
• Keywords: fluorine, biomolecules, peptides, amino acids, NMR spectroscopy, pharmacokinetics
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2026
• Number of pages: Str. 8473-8486
• Numbering: Vol. 91, iss. 25
• PID: 20.500.12556/RUL-186943
• UDC: 546.16:547.9
• ISSN on article: 0022-3263
• DOI: 10.1021/acs.joc.6c00904
• COBISS.SI-ID: 282047235
• Publication date in RUL: 07.09.2026

Record is a part of a journal

• Title: Journal of organic chemistry
• Shortened title: J. org. chem.
• Publisher: American Chemical Society.
• ISSN: 0022-3263
• COBISS.SI-ID: 235287

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: fluor, biomolekule, peptidi, aminokisline, NMR spektroskopija, farmakokinetika