Sinteza 4-okso-4H-pirido[1,2-a]pirimidin-3-diazonijevega tetrafluoroborata

Koman, Jernej (author), Svete, Jurij (mentor)

V diplomski nalogi sem po petstopenjskem postopku iz hipurne kisline sintetiziral 4-okso-4H-pirido[1,2-a]pirimidin-3-diazonijev tetrafluoroborat, ki je uporaben intermediat v sintezi heterociklov in biokonjugaciji. Končni produkt in vse intermediate sem okarakteriziral z IR in 1H NMR spektroskopijo, štiri spojine pa tudi z elementno analizo za C, H in N. Ugotovil sem tudi, da se je spojina 3-amino-4-okso-4H-pirido[1,2-a]pirimidin ob obarjanju iz raztopine izločila v obliki dihidrokloridne soli.

• Language: Slovenian
• Keywords: 4-okso-4H-pirido[1, 2-a]pirimidin-3-diazonijev tetrafluoroborat, organska sinteza, biokonjugacija, fluorescenca, diazonijeve soli
• Work type: Bachelor thesis/paper
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2026
• PID: 20.500.12556/RUL-186931
• Publication date in RUL: 07.09.2026

Secondary language

• Language: English
• Title: Synthesis of 4-oxo-4H-pyrido[1,2-a]pyrimidin-3-diazonium tetrafluoroborate

Abstract

In this thesis 4-oxo-4H-pyrido[1,2-a]pyrimidin-3-diazonium tetrafluoroborate, a useful intermediate in the synthesis of heterocycles and bioconjugation, was synthesized in five steps from hippuric acid. The final product and all intermediates were characterized by IR and 1H NMR spectroscopy; four out of five compounds were also characterized by elemental analysis for C, H, and N. I also found out that 3-amino-4-oxo-4H-pyrido[1,2-a]pyrimidine precipitated from the solution as a dihydrochloride salt.

• Keywords: 4-oxo-4H-pyrido[1, 2-a]pyrimidine-3-diazonium tetrafluoroborate, organic synthesis, bioconjugation, fluorescence, diazonium salts