Beta-(1,3/1,6)-D-glucan from Pleurotus ostreatus in the prevention of recurrent respiratory tract infections : an international, multicentre, open-label, prospective study

Rennerova, Zuzana (author), Picó Sirvent, Leonardo (author), Carvajal Roca, Eva (author), Paśnik, Jaroslaw (author), Logar, Mateja (author), Milosevic, Katarina (author), Majtan, Juraj (author), Ješenák, Miloš (author)

Preschool children are particularly susceptible to recurrent upper and lower respiratory tract infections due to their immune immaturity and other contributing factors. Preventing and/or treating children suffering from recurrent respiratory tract infections (RRTIs) is challenging, and it is important to provide more clinical evidence about the safety and efficacy of natural immunomodulating preparations, including β-glucans. The aim of the present study was to assess the incidence of respiratory tract infections (RTIs) in children with a history of RRTIs for a period of 6 months (3 months of pleuran supplementation and 3 months of follow-up) compared with the same period from October to March of the previous year prior to enrolment in the study. A total of 1,030 children with a mean age of 3.49 ± 1.91 years from seven countries were included in this study. The total number of RTIs observed during the study period was significantly lower compared to the same period of the previous year (7.07 ± 2.89 vs. 3.87 ± 3.19; p < 0.001). Analysis of each type of RTI revealed significant reductions in the mean number and duration of infections for all RTI subtypes compared to the previous year. This study also confirmed the beneficial safety profile of pleuran supplementation. In conclusion, pleuran supplementation represents an interesting and prospective supplement in preventing respiratory infections and reveals new strategies for supporting immune functions in the paediatric population.

• Language: English
• Keywords: pleuran, respiratory tract infections, beta-glucan, children, tolerability
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 8 str.
• Numbering: Vol. 10, art. 999701
• PID: 20.500.12556/RUL-186550
• UDC: 616.2
• ISSN on article: 2296-2360
• DOI: 10.3389/fped.2022.999701
• COBISS.SI-ID: 147683331
• Publication date in RUL: 10.09.2026

Record is a part of a journal

• Title: Frontiers in pediatrics
• Shortened title: Front. pediatr.
• Publisher: Frontiers Media
• ISSN: 2296-2360
• COBISS.SI-ID: 523096601

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Undetermined
• Keywords: plevran, okužba dihalnih poti, beta-glukan, otroci, prenašanje

Projects

• Funder: Other - Other funder or multiple funders
• Funding programme: Pleuran Ltd