Anteromedial globus pallidus internus deep brain stimulation for Gilles de la Tourette syndrome : a two-case report and review of the literature

Felbabić, Tomislav (author), Berlot, Rok (author), Trošt, Maja (author), Georgiev, Dejan (author), Benedičič, Mitja (author)

Background: Gilles de la Tourette syndrome is a neurobehavioral disorder that typically begins in childhood, subsides during puberty, and may reappear in adolescence. Treatment is primarily conservative, involving psychological and pharmacological therapy. Patients who do not respond to conservative therapy may be treated with deep brain stimulation, although this remains an experimental treatment. Methods: In this two-case report we present the first two cases of patients with Gilles de la Tourette syndrome in Slovenia treated with deep brain stimulation of the anteromedial globus pallidus internus. Results: Over an 18-month follow-up period, we observed an improvement in both cases. In the first case, the Yale Global Tic Severity Scale score decreased from 71 (17 for motor tics, 14 for phonic tics, and 40 on the impairment scale) to 44 points (12 motor, 12 phonic, and 20 impairment). In the second case, the score decreased from 72 (16 motor, 16 phonic, and 40 impairment) to 38 points (8 motor, 10 phonic, and 20 impairment). Conclusions: Deep brain stimulation could be a promising treatment for this disorder. However, further research is needed to determine the most suitable patients and targets.

• Language: English
• Keywords: deep brain stimulation, Gilles de la Tourette syndrome, anteromedial globus pallidus internus
• Work type: Article
• Typology: 1.03 - Other scientific articles
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2026
• Number of pages: 9 str.
• Numbering: Vol. 18, iss. 2, art. 21
• PID: 20.500.12556/RUL-186344
• UDC: 616.8
• ISSN on article: 2035-8377
• DOI: 10.3390/neurolint18020021
• COBISS.SI-ID: 266297091
• Publication date in RUL: 31.08.2026

Record is a part of a journal

• Title: Neurology international
• Shortened title: Neurol. int.
• Publisher: MDPI
• ISSN: 2035-8377
• COBISS.SI-ID: 517576217

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: globoka možganska stimulacija, sindrom Gilles de la Tourette, anteromedialni del globus pallidus internus