Bone is a multifunctional organ whose anisotropic and heterogeneous structure, together with the dependence of its mechanical properties on strain rate, makes it a challenging material for both experimental and numerical investigations. This thesis focuses on the selection and evaluation of existing material models suitable for predicting the mechanical response of cortical bone under different strain rates. A specimen preparation procedure was established through the design of a dedicated fixation system and the machining of porcine femoral bone samples. Hardness measurements performed on the specimen surfaces revealed differences between the longitudinal and transverse directions. Based on the specimen geometry, a digital twin was created and used in numerical simulations under identical boundary conditions while applying different material models. The numerical results were analysed and used to design the experimental compression test, including the selection of the testing fixture, test parameters, and recommended measuring equipment. The proposed methodology provides a basis for future experimental validation of numerical models describing the mechanical response of cortical bone.
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