Black mulberry fruit extract attenuates valproic acid-induced toxicity by enhancing antioxidant defenses in FaO cells : research data underlying the article

Oblak, Iza (author), Pavlović, Nebojša (author), Vukmirović, Saša (author), Šuput, Dušan (author), Stilinović, Nebojša (author), Milisav, Irina (author)

This dataset contains the numerical data underlying the figures presented in the article “Mulberry fruit extract attenuates valproic acid-induced oxidative injury and increases glutathione peroxidase activity in FaO cells.” The study investigated whether black mulberry (Morus nigra L.) fruit extract modifies valproic acid-induced toxicity and oxidative stress in FaO rat hepatoma cells following acute exposure to valproic acid for 28 hours or chronic exposure for 4 weeks. The deposited data include measurements of cell viability and fitness, hepatocellular injury, oxidative status, antioxidant enzyme activities, and extracellular antioxidant capacity. The analyzed outcomes include neutral red accumulation, extracellular alanine aminotransferase activity, hydrogen peroxide production, cellular antioxidant enzyme activities, and ABTS radical-scavenging capacity, as applicable to the acute and chronic experiments. The file provides the values used to generate the article figures, including individual biological replicate values.

• Language: English
• Keywords: hepatotoxicity, antioxidants, plant extracts, oxidative stress, valproic acid, mulberry, liver cells
• Typology: 2.20 - Research data
• Temporal coverage: From 2023-02-01 to 2026-07-20
• Organization: MF - Faculty of Medicine
• Year: 2026
• PID: 20.500.12556/RUL-185368
• Data col. methods: Measurements and tests

Note

Povezan članek/Related article: Oblak, I., Pavlović, N., Vukmirović, S., Šuput, D., Stilinović, N., Milisav, I., Black mulberry fruit extract attenuates valproic acid-induced toxicity by enhancing antioxidant defenses in FaO cells, Biomolecules and Biomedicine, 2026, https://doi.org/10.17305/bb.2026.14532

• Publication date in RUL: 03.08.2026

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
• Applies to: publication

Secondary language

• Language: Slovenian
• Keywords: hepatotoksičnost, antioksidanti, rastlinski izvlečki, oksidativni stres, valprojska kislina, murva, jetrne celice

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P3-0019
• Name: Aplikativna in bazična fiziologija in patofiziologija v medicini