An overview and recent developments in the analysis of multistate processes

Gorfine, Malka (author), Cook, Richard John (author), Andersen, Per Kragh (author), Therneau, Terry M. (author), Joly, Pierre (author), Putter, Hein (author), Pohar Perme, Maja (author), Abrahamowicz, Michal (author)

Multistate models offer a powerful framework for studying disease processes and can be used to formulate intensity-based and more descriptive marginal regression models. They also represent a natural foundation for the construction of joint models for disease processes and dynamic marker processes, as well as joint models incorporating random censoring and intermittent observation times. This article reviews the ways multistate models can be formed and fitted to life history data. Recent work on pseudo-values and the incorporation of random effects to model dependence on the process history and between-process heterogeneity are also discussed. The software available to facilitate such analyses is listed.

• Language: English
• Keywords: frailty, process history, pseudo-values, state occupancy probability, time‐dependent covariates, transition intensity
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2026
• Number of pages: 27 str.
• Numbering: Vol. 45, iss. 10/12, art. e70493
• PID: 20.500.12556/RUL-182758
• UDC: 311:519.24
• ISSN on article: 0277-6715
• DOI: 10.1002/sim.70493
• COBISS.SI-ID: 278917379
• Publication date in RUL: 22.05.2026

Record is a part of a journal

• Title: Statistics in medicine
• Shortened title: Stat. med.
• Publisher: Wiley
• ISSN: 0277-6715
• COBISS.SI-ID: 502292

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: krhkost, zgodovina procesa, psevdovrednosti, verjetnost zasedenosti stanja, časovno odvisne kovariance, intenziteta prehoda