Preconception use of GLP-1 and GLP-1/GIP receptor agonists for obesity treatment

Koceva, Andrijana (author), Janež, Andrej (author), Jensterle Sever, Mojca (author)

Obesity is rising among women of reproductive age and significantly contributes to subfertility. If conception occurs, maternal obesity is associated with increased risks for both maternal and neonatal complications, with potential long-term effects on the offspring's health. Current clinical guidelines emphasize the importance of preconception weight optimization in women with obesity to reduce maternal and fetal risks. Amid the rising use of incretin-based anti-obesity medications, particularly among young women, their potential role in preconception care is receiving growing clinical and research interest. With unplanned pregnancies remaining common, incidental exposure during early pregnancy is becoming more likely. In parallel, there is increasing interest in the potential of these agents to support preconception weight loss and enhance fertility outcomes in women with obesity. This narrative review examines the current human evidence on GLP-1 and dual GLP-1/GIP receptor agonists approved for obesity treatment, focusing on their potential role in preconception care and addressing key safety considerations and challenges related to their use during the preconception period, as well as inadvertent exposure in early pregnancy.

• Language: English
• Keywords: GLP-1 receptor agonist, GLP-1/GIP receptor agonist, preconception care, liraglutide, semaglutide, tirzepatide
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: 10 str.
• Numbering: Vol. 39, iss. 6, art. 102038
• PID: 20.500.12556/RUL-182728
• UDC: 616.4
• ISSN on article: 1521-690X
• DOI: 10.1016/j.beem.2025.102038
• COBISS.SI-ID: 250744067
• Publication date in RUL: 21.05.2026

Record is a part of a journal

• Title: Baillière's best practice & research. Clinical endocrinology and metabolism
• Shortened title: Baillière's best pract. res. Clin. endocrinol. metab.
• Publisher: Elsevier
• ISSN: 1521-690X
• COBISS.SI-ID: 2071060

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: agonist receptorja GLP-1, agonist receptorja GLP-1/GIP, predzanositvena oskrba