Immobilized and recyclable catalysts for deuterium labelling : recent developments and emerging strategies

Raju, Liju (author), Jedlovčnik, Luka (author), Košmrlj, Janez (author), Jansen-van Vuuren, Ross D. (author)

Deuterated compounds have become indispensable across a wide range of applications in medicinal chemistry and materials science, driving interest in the development of efficient and sustainable synthetic methodologies. In particular, there is a growing emphasis on greener approaches that enable deuteration under mild conditions which typically necessitate the use of catalytic systems. While homogeneous catalysts are often employed due to their high activity, their limited recoverability can lead to inefficiencies, waste generation, and potential product contamination. To address these challenges, increasing attention has been directed toward the use of immobilized and recyclable catalysts, which offer enhanced sustainability and operational advantages. Such systems not only facilitate catalyst recovery and reuse but also enable integration with continuous flow technologies, providing a promising route toward scalable and environmentally responsible deuteration processes. In this review, we survey recent advances (since June 2024) in the application of immobilized and recyclable catalysts for deuteration, with a focus on innovative materials, catalytic strategies, and emerging trends that are shaping the future of this field.

• Language: English
• Keywords: immobilized, suitable for recycling, catalyst, deuteration, continuous-flow chemistry, isotope exchange, deuterium labeling, carrier
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2026
• Number of pages: Str. 3112-3146
• Numbering: Vol. 4, iss. 8
• PID: 20.500.12556/RUL-182532
• UDC: 547.5:546.11.027*2:544.478
• ISSN on article: 2753-8125
• DOI: 10.1039/D6SU00003G
• COBISS.SI-ID: 277349379
• Publication date in RUL: 15.05.2026

Record is a part of a journal

• Title: RSC sustainability
• Shortened title: RSC sustain.
• Publisher: Royal Society of Chemistry
• ISSN: 2753-8125
• COBISS.SI-ID: 175932931

Licences

• License: CC BY 3.0, Creative Commons Attribution 3.0 Unported
• Link: https://creativecommons.org/licenses/by/3.0/deed.en
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material for any purpose, even commercially. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Secondary language

• Language: Slovenian
• Keywords: imobiliziran, primeren za recikliranje, katalizator, deuteriranje, kemija s kontinuiranim pretokom, izotopska izmenjava, označevanje z devterijem, nosilec