Reakcija fluoriranja organskih molekul s fluoridom v globokih evtektičnih topilih

Hrastar, Luka (author), Iskra, Jernej (mentor)

V diplomski nalogi sem raziskal lastnosti globokih evtektičnih topil (DES) kot reakcijskega medija za reakcije fluoriranja organskih molekul. Glede na ključno vlogo vodikovih vezi pri strukturi in reaktivnosti DES ter na sposobnost fluoridnih ionov, da tvorijo močne vodikove vezi, sem se osredotočil na njihovo nukleofilno aktivnost v takih sistemih. Najprej sem analiziral literaturo o interakcijah fluoridnih ionov z različnimi kombinacijami donorjev in akceptorjev vodikovih vezi ter identificiral ustrezne sestave za pripravo stabilnih DES, ki bi vsebovali fluoridne ione. Nato sem preučil primere uporabe fluoridnih ionov kot reagentov ali funkcionalnih dodatkov v DES sistemih. Na koncu sem obravnaval reakcije nukleofilnega fluoriranja organskih spojin z uporabo enostavnih fluoridnih soli v DES. Pri tem sem se naslanjal na podatke iz znanstvenih baz Scopus in Web of Science ter izključno na izvirne recenzirane vire.

• Language: Slovenian
• Keywords: Globoka evtektična topila (DES), fluoridni ion, nukleofilno fluoriranje, vodikove vezi, reaktivnost.
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2026
• PID: 20.500.12556/RUL-181719
• COBISS.SI-ID: 275386371
• Publication date in RUL: 14.04.2026

Secondary language

• Language: English
• Title: Reaction of fluorination of organic molecules with fluoride in deep eutectic solvents

Abstract

In this thesis, I investigated the properties of deep eutectic solvents (DES) as reaction media for the fluorination reactions of organic molecules. Given the key role of hydrogen bonding in the structure and reactivity of DES, and the ability of the fluoride ion to form strong hydrogen bonds, I focused on its nucleophilic activity in such systems. First, I analyzed the literature on fluoride interactions with various combinations of hydrogen-bond donors and acceptors and identified suitable compositions for preparing stable, fluoride ions-containing DES. I then examined examples in which fluoride is used as an external reagent or as a functional additive in DES systems. Finally, I addressed nucleophilic fluorination reactions of organic compounds using simple fluoride salts in DES. The work draws on data from the Scopus and Web of Science databases and relies exclusively on original, peer-reviewed sources.

• Keywords: Deep eutectic solvents (DES), fluoride ion, nucleophilic fluorination, hydrogen bonding, reactivity.