Aminoglycoside antibiotics as first-line treatment of acute appendicitis and cholecystitis

Šetinc, Lučka (author), Pintar, Tadeja (author), Zafirovski, Aleksandar (author), Godnov, Uroš (author), Beović, Bojana (author)

We analyzed the efficacy and safety of aminoglycosides in a retrospective study of 415 patients with acute appendicitis and 277 patients with acute cholecystitis. The following variables increased the incidence of postoperative complications, defined as surgical site infection, recurrent intraabdominal infection, non-infectious post-operative complication, or death: age (p = 0.016 and 0.011), kidney disease (p = 0.019 and <0.001), and ASA Score (p < 0.001). The type of antibiotic therapy did not have a statistically significant effect on the incidence of postoperative complications in patients with acute appendicitis and cholecystitis (p = 0.561 and 0.547, respectively). A linear regression model showed a higher complication rate in patients with kidney disease (p = 0.014) and neoplasms (p = 0.013); the type of antibiotic therapy did not have a significant effect on the outcome (p = 0.765). There was no statistically significant difference in the post-treatment levels of creatinine in patients treated with aminoglycosides (gentamicin 3 mg/kg once daily) and in those who received other antibiotics (p = 0.75).

• Language: English
• Keywords: aminoglycoside, antibiotics, antimicrobial resistance, intraabdominal infection, nephrotoxicity, risk factors
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: Str. 307-316
• Numbering: Vol. 37, no. 4
• PID: 20.500.12556/RUL-176008
• UDC: 616-07
• ISSN on article: 1973-9478
• DOI: 10.1080/1120009X.2024.2381158
• COBISS.SI-ID: 203877379
• Publication date in RUL: 18.11.2025

Record is a part of a journal

• Title: Journal of chemotherapy
• Shortened title: J. chemother.
• Publisher: Taylor & Francis, Italian Society of Chemotherapy
• ISSN: 1973-9478
• COBISS.SI-ID: 521573145

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: aminoglikozid, antibiotiki, protimikrobna odpornost, intraabdominalna okužba, nefrotoksičnost, dejavniki tveganja