Oxidative stress-related biomarkers in inflammatory bowel disease : dual tools for remission assessment and prediction of treatment outcome

Tratenšek, Armando (author), Grabnar, Iztok (author), Drobne, David (author), Vovk, Tomaž (author)

Oxidative stress is increasingly recognized as a significant contributor to the pathogenesis of inflammatory bowel disease (IBD). However, the clinical utility of oxidative stress-related biomarkers for assessing and predicting disease activity remains unclear. This prospective observational study aimed to evaluate the diagnostic and predictive performance of oxidative stress-related biomarkers in distinguishing between active IBD and remission across clinical, biochemical, and endoscopic criteria. A total of 76 patients with IBD were followed across three visits: baseline (biological treatment initiation), post-induction (6–12 weeks), and final follow-up (24–36 weeks). Associations with clinical, biochemical, and endoscopic remission status at the final follow-up were evaluated using correlation matrices, receiver operating characteristic curve analysis, principal component analysis, and logistic regression. Ceruloplasmin, plasma free thiols, gamma-glutamyl transferase, and albumin showed significant diagnostic values for distinguishing active disease from remission, using C-reactive protein (CRP)-based criteria. Serum uric acid, advanced oxidation protein products, gamma-glutamyl transferase, total antioxidant capacity, and ceruloplasmin predicted clinical or CRP-based remission when measured at baseline or post-induction, with predictive value varying by biomarker and the time point. Overall, our findings reinforce the role of oxidative stress in the pathogenesis of IBD and highlight the potential of oxidative stress-related biomarkers to be used as tools for monitoring disease activity and predicting IBD treatment outcomes.

• Language: English
• Keywords: inflammatory bowel disease, ulcerative colitis, Crohn’s disease, oxidative stress, biomarker, remission
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: 24 str.
• Numbering: Vol. 14, iss. 10, [article no.] 1183
• PID: 20.500.12556/RUL-175621
• UDC: 616.344-002+612.015
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox14101183
• COBISS.SI-ID: 250803971
• Publication date in RUL: 06.11.2025

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI AG
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: vnetna črevesna bolezen, ulcerozni kolitis, biomarkerji, remisija, Crohnova bolezen, oksidativni stres

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0189
• Name: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: J3-4499
• Name: MEHANIZMI ODZIVA NA IL 12/23 ZAVIRALCE PRI ULCEROZNEM KOLITISU - NAPROTI PERSONALIZIRANI MEDICINI