Acil-substituirani (hetero)aromati in njihovi analogi v sintezi enaminonov

Krumpačnik, Nika (author), Grošelj, Uroš (mentor)

V diplomskem delu je predstavljena sinteza serije enaminonov iz acil-substituiranih (hetero)aromatov in njihovih analogov. Osredotočila sem se na preverjanje uspešnosti izbranih sinteznih poti in pripravo izbranih enaminonov, ki bodo uporabljeni v nadaljnjih fotoredoks kataliziranih pretvorbah. Sinteze so temeljile na uporabi N,N-dimetilformamid dimetil acetala (DMFDMA), ki je z izbranimi izhodnimi substrati reagiral preko aktivne metilenske skupine oziroma preko aktivne metilne skupine.

• Language: Slovenian
• Keywords: sinteza, enaminoni, DMFDMA, aktivna metilenska skupina, aktivna metilna skupina
• Work type: Bachelor thesis/paper
• Typology: 2.11 - Undergraduate Thesis
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2025
• PID: 20.500.12556/RUL-175198
• COBISS.SI-ID: 259108611
• Publication date in RUL: 21.10.2025

Secondary language

• Language: English
• Title: Acyl-substituted (hetero)aromatic compounds and their analogs in the synthesis of enaminones

Abstract

In this work, the synthesis of enaminones from selected acyl-substituted (hetero)aromatic compounds and their analogs is presented. The focus was on evaluating the efficiency of selected synthetic routes and preparing enaminones intended for subsequent photoredox-catalyzed transformations. The syntheses used N,N-dimethylformamide dimethylacetal (DMFDMA), which reacted with selected starting substrates via an active methylene or methyl group.

• Keywords: synthesis, enaminones, DMFDMA, active methylene group, active methyl group.