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Numerična simulacija tvorbe polipa zaradi sekundarne izgube stabilnosti rastočih filmov na mehkih viskoelastičnih podlagah
ID Zavodnik, Špela (Author), ID Brojan, Miha (Mentor) More about this mentor... This link opens in a new window

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Abstract
Za razumevanje kompleksnih biomehanskih mehanizmov, ki so vzrok za oblikovanje polipov v mehkih bioloških tkivih, smo analizirali relativno preprost prototipični primer gubanja rastočega tankega kolobarja (filma) na mehki viskoelastični podlagi. Ta primer smo obravnavali v programskem okolju FEniCS, ki vključuje tudi osnovne algoritme za reševanje parcialnih diferencialnih enačb, kot je Newton-Raphsonova metoda. Na podlagi izvedenih simulacij smo ugotovili, da na število gub in posledično število nastalih polipov vplivajo debelina tankega filma, notranji radij ter razmerje togosti podlage in filma. V nekaterih primerih pa smo opazili nepričakovane deformacijske oblike, ki jih ni mogoče predvideti na enostaven način, saj nastanejo zaradi nepojasnjenih preskokov sistema, ki so posledica nelinearne narave sistema zaradi geometrije in nelinearnega materialnega modela mehkih tkiv.

Language:Slovenian
Keywords:numerična simulacija, mehka tkiva, gubanje, polipi, visko-hiperelastičnost, viskoelastične podlage, bifurkacija
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FS - Faculty of Mechanical Engineering
Year:2025
Number of pages:XVIII, 62 str.
PID:20.500.12556/RUL-173158 This link opens in a new window
UDC:620.174:544.236.4:004.942(043.2)
COBISS.SI-ID:249475075 This link opens in a new window
Publication date in RUL:13.09.2025
Views:144
Downloads:0
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Secondary language

Language:English
Title:Numerical simulation of the polyp formation due to secondary loss of stability in growing films on a soft viscoelastic substrates
Abstract:
To understand the complex biomechanical mechanisms that cause polyp formation in soft biological tissues, we performed an analysis of a relatively simple, prototypical example of wrinkling of a growing thin ring (film) on a soft viscoelastic substrate. We addressed this example in the FEniCS programming environment, which also includes basic algorithms for solving partial differential equations, such as the Newton-Raphson method. Based on the simulations performed, we found that the number of wrinkles, and consequently the number of resulting polyps, is influenced by the film's thickness, its inner radius, and the stiffness ratio between the substrate and the film. In some cases, however, we observed unexpected deformation shapes that cannot be easily predicted. These arise from unexplained jumps in the system, which are a consequence of the system's nonlinear nature due to its geometry and the nonlinear material model of soft tissues.

Keywords:numerical simulation, soft tissues, buckling, polyps, visco-hyperelasticity, viscoelastic substrates, bifurcation

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