This master’s thesis investigates heat transfer in pharmaceutical packaging using both experimental and numerical approaches. Time-dependent temperature measurements were conducted on a 1-litre bottle containing a frozen medium, transitioning from a deep-freeze chamber to ambient conditions. Measurements at three key locations enabled precise monitoring of thermal behaviour. Based on the experimental data, a numerical model was developed using the finite element method (FEM) in Ansys Workbench. The model was validated using statistical values (RMSE, MAE, R²), which demonstrated a high degree of agreement between simulation and measurements. The results confirm that the numerical model is reliable and applicable for predicting thermal response in real-world handling scenarios. This contributes to the optimisation of procedures for managing temperature-sensitive pharmaceutical products and supports the development of robust quality assurance guidelines in pharmaceutical logistics.
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