Synthesis of a fac-tricarbonylrhenium(I) complex with pyrithione, its physicochemical characterization, and assessment of biological effects

Rapuš, Uroš (author), Pivarcsik, Tamás (author), Mitrović, Ana (author), Kljun, Jakob (author), Bogdanov, Anita (author), Spengler, Gabriella (author), Meden, Anže (author), Gobec, Stanislav (author), Kos, Janko (author), Enyedy, Éva Anna (author), Turel, Iztok (author)

Research on rhenium complexes containing fac-tricarbonyl fragments has been on the rise in recent decades. Some complexes of this type exhibit advantageous properties that can be utilized in diagnostic and therapeutic applications. Herein, we report on the synthesis, structural characterization, solution speciation, and biological activity with mode of action studies of a new fac-tricarbonylrhenium(I) complex with pyrithione ligand fac-[Re(CO)$_3$(pyrithionato)(benzonitrile)] (4). In an attempt to prepare a stable rhenium(I) complex with a pyrithionato ligand, several synthesis procedures were investigated and various products were discovered. In solution, the monodentate benzonitrile ligand can be replaced by a coordinating solvent molecule; however, the carbonyl ligands and pyrithione remain bound to the rhenium center. Complex 4 exhibited strong cytotoxic and antibacterial activity and effectively inhibited the growth of the HSV-2 virus. Additionally, complex 4 was also able to inhibit the cathepsin B enzyme (both its endo- and exopeptidase activities). In silico experiments confirmed that complex 4 can interact with cathepsin B near its active site, which may contribute to reduced enzymatic activity.

• Language: English
• Keywords: antimicrobial agents, degradation, inhibition, ligands, peptides, proteins
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology; FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: Str. 38272-38291
• Numbering: Vol. 10, iss. 33
• PID: 20.500.12556/RUL-172601
• UDC: 546.719:547.82
• ISSN on article: 2470-1343
• DOI: 10.1021/acsomega.5c06647
• COBISS.SI-ID: 247217923
• Publication date in RUL: 09.09.2025

Record is a part of a journal

• Title: ACS omega
• Shortened title: ACS omega
• Publisher: American Chemical Society
• ISSN: 2470-1343
• COBISS.SI-ID: 525873945

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: renij, trikarbonilrenijevi(I) kompleksi, pirition, biološka aktivnost