In my thesis, I described the synthesis of N-butyl-2-phenylimidazole and its subsequent functionalization at the ortho position of the phenyl ring via C–H activation in the presence of a ruthenium catalyst ([Ru(p-cymene)Cl2]2). I presented the properties of imidazole and the theoretical background of classical cross-coupling reactions, as well as the direct functionalization of C–H bonds. In the experimental part, I first carried out the synthesis of N-butyl-2-phenylimidazole, followed by an investigation of the influence of different aryl bromides as substituents on the progress of the C–H activation reaction. The reactions were performed using 4-bromotoluene, 4-bromoacetophenone, 1-bromo-4-trifluoromethylbenzene, and 4-bromoanisole first in water without any added ligands, and then in toluene with added ligands KOPiv and PPh3.
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