In this thesis, I focus on the synthesis of various 5,6-disubstituted 2H-pyran-2-ones. The starting point for the design of the synthesis is the one-pot synthetic method according to Kepe and its later modifications. For the starting compounds, I used various activated electrophiles, 1,3-diketones, and cycloalkanones. I reacted them with hippuric acid as the N-acylglycine and DMFDMA as the C1-synthon. I successfully prepared two analogues: a mono- and a bicyclic 5,6-disubstituted 3-benzoylamino-2H-pyran-2-one. As a further transformation, I first investigated the removal of the 3-acylamino group by hot acid hydrolysis of the amide bond. The 3-amino analogue was successfully isolated with a good yield. On the same product, I attempted to introduce a new protecting group with acryloyl chloride. 2H-pyran-2-ones and their derivatives can serve as scaffolds of important biologically active molecules that are crucial in the development of medicinal chemistry and new drugs.
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