Introduction: End-stage renal disease is an irreversible loss of kidney function and requires replacement therapy, most commonly hemodialysis. The condition significantly affects the quality of life of both patients and their close family members. Long-term dialysis often negatively impacts patients' mental health, increasing the risk of depression, anxiety, and social isolation. Purpose: This thesis aimed to explore the psychosocial aspects of quality of life in patients undergoing long-term dialysis and the impact of the disease and frequent dialysis sessions on family relationships. It also sought to determine whether nurses can influence patient's lifestyle changes and their perception of quality of life. Methods: A review of scientific and professional literature in English and Slovenian, published between 2014 and 2024, was conducted. Relevant literature was obtained from databases such as PubMed, CINAHL Ultimate, MEDLINE, and Google Scholar. Results: The treatment affects family relationships, causing stress, uncertainty, and major lifestyle adjustments. Discussion and Conclusion: Long-term dialysis treatment has a negative impact on patients’ mental health, quality of life, and family relationships. Nurses play a key role in mitigating these effects by providing support and education, thereby significantly improving patients’ quality of life and reducing the negative impact of the disease. Holistic psychosocial support for patients and their families, along with attention to nurses' well-being, is essential for improving the quality of life of dialysis patients and enabling nurses to provide effective care.
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