Towards a multi-omics understanding of anaphylaxis : insights into pathogenesis and biomarker identification

Svetina, Manca (author), Kunej, Tanja (author), Korošec, Peter (author), Rijavec, Matija (author)

Anaphylaxis is a severe, life-threatening hypersensitivity reaction that presents significant challenges in both clinical practice and scientific research. While individual omics studies have provided valuable insights into the genetic predisposition, immune dysregulation, and metabolic alterations associated with anaphylaxis, a comprehensive understanding of its full pathophysiology remains elusive. Multi-omics integration, which combines genomics, epigenomics, transcriptomics, proteomics, and metabolomics, has the potential to uncover novel mechanisms, biomarkers, and therapeutic targets. However, studies employing comprehensive multi-omics approaches in anaphylaxis are still limited. This review of 107 studies published between 2000 and 2024—including genomics (43), metagenomics (2), epigenomics (2), transcriptomics (20), proteomics (26), and metabolomics (14)—synthesizes findings from existing single-omics studies on human anaphylaxis, identifies key interconnections across omics layers, and underscores the critical need for large-scale, integrative research. Advancing this type of research is essential to advance our understanding of anaphylaxis, improve risk prediction, and enhance both diagnosis and treatment strategies.

• Language: English
• Keywords: anaphylaxis, multi-omics, pathophysiology, biomarker, precision medicine
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty; FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: 18 str.
• Numbering: Vol. 68, art. 61
• PID: 20.500.12556/RUL-170318
• UDC: 577.27
• ISSN on article: 1080-0549
• DOI: 10.1007/s12016-025-09069-8
• COBISS.SI-ID: 241003267
• Publication date in RUL: 03.07.2025

Record is a part of a journal

• Title: Clinical reviews in allergy & immunology
• Shortened title: Clin. rev. allergy immunol.
• Publisher: Humana Press
• ISSN: 1080-0549
• COBISS.SI-ID: 514834713

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: anafilaksija, patogeneza, biomarkerji, omike