Introduction: Bullous pemphigoid is the most common autoimmune bullous chronic disease affecting the skin and, in some cases, mucous membranes. It primarily occurs in the elderly population. The most frequent symptom is itching and the formation of blisters that are filled with clean fluid, or sometimes they may contain some blood. The most commonly affected areas are the hands and feet, though the oral mucosa may also be involved. Less commonly, the conjunctiva, nose, pharynx, larynx, esophagus, trachea, and anogenital region can be affected. The occurrence of this disease has been increasing over the past few decades, due to longer life expectancy. Possible triggers include the use of certain medications, vaccinations, exposure to UV rays, injuries, infections, and surgeries. Early identification of the condition and prompt medical attention are essential. The sooner the condition is addressed, the better the disease prognosis. Purpose: The aim of this thesis was to present the disease bullous pemphigoid, investigate how it affects the physical, psychological, social and spiritual well-being of patients and their daily lives. Methods: A descriptive research method was used, involving a review of relevant professional and scientific literature. Searches were conducted in the following databases: PubMed, Medline, ScienceDirect and additional research through the Google Scholar search engine. Results and discussion: Research highlights that bullous pemphigoid disease significantly affects quality of life, mainly due to itching, which impairs sleep, causes psychological problems and limits daily activities. Standard treatment, using local steroids and systemic corticosteroids, reduces the intensity of the disease and improves quality of life, with psychological support remaining key to the comprehensive treatment of patients. Stress, fatigue and dry skin worsen symptoms, while cold water temporarily relieves them. Conclusion: The quality of life of patients with bullous pemphigoid is worse compared to healthy individuals. It affects all aspects of health and interferes with patient’s daily lives. Activities such as sleeping, concentrating, learning, performing work duties, as well as feelings of shame and irritability, are impacted. The most bothersome symptom is itching, which causes a strong and frequent urge to scratch. Health education by healthcare professionals and encouragement to treat bullous pemphigoid are important, as they significantly contribute to improved well-being.
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