On zinc(II) coordination chemistry with furosemide : a journey from a mononuclear complex to a coordination polymer

Podjed Rihtaršič, Nina (author), Uranjek, Zarja (author), Cerc Korošec, Romana (author), Hrast, Martina (author), Golob, Majda (author), Modec, Barbara (author)

In continuation of our studies on zinc(II) coordination chemistry, reactions between the zinc(II) starting material and furosemide were investigated. Furosemide, a well-known pharmaceutical, contains functional groups which could serve as donors in coordination with metal ions. Reactions between zinc oxide or chloride and furosemide in aqueous ammonia solution yielded a mononuclear complex, [Zn(NH$_3$)$_2$(fur)$_2$] (1), where fur− stands for deprotonated furosemide. Unfortunately, some reactions produced mixtures of the desired metal complex 1 and by-product, ammonium salt NH$_4$fur (2). To further explore the coordination chemistry of furosemide, quinaldinate (an anion of quinoline-2-carboxylic acid, abbreviated as quin$^−$) was introduced into the reaction system, resulting in the formation of a coordination polymer, [Zn$_3$(quin)$_4$(fur)$_2$]$_n$·2nCH$_3$OH (3). 1 and 3 were evaluated for their antibacterial properties against Gram-positive and Gram-negative bacteria. Notably, compound 3 exhibited moderate antibacterial activity against Staphylococcus epidermidis, representing a promising starting point for the preparation of potential antibacterial zinc(II) complexes.

• Language: English
• Keywords: furosemide, quinaldinate, zinc(II), coordination compounds, polymer, crystal structure, antibacterial activity
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: Str. 9113-9122
• Numbering: Vol. 49, iss. 22
• PID: 20.500.12556/RUL-169567
• UDC: 546.47
• ISSN on article: 1369-9261
• DOI: 10.1039/D5NJ01438G
• COBISS.SI-ID: 238212611
• Publication date in RUL: 04.06.2025

Record is a part of a journal

• Title: New journal of chemistry
• Shortened title: New j. chem.
• Publisher: Royal Society of Chemistry
• ISSN: 1369-9261
• COBISS.SI-ID: 22573573

Licences

• License: CC BY-NC 3.0, Creative Commons Attribution-NonCommercial 3.0 Unported
• Link: http://creativecommons.org/licenses/by-nc/3.0/
• Description: You are free to reproduce and redistribute the material in any medium or format. You are free to remix, transform, and build upon the material. You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use. You may not use the material for commercial purposes. You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Secondary language

• Language: Slovenian
• Keywords: furosemid, kinaldinat, cink(II), koordinacijske spojine, polimer, kristalna struktura, antibakterijska aktivnost