Prevention and treatment of antibiotics-associated adverse effects through the use of probiotics : a review

Yang, Shuwei (author), Qiao, Jiaqi (author), Zhang, Meng (author), Kwok, Lai-Yu (author), Bogovič Matijašić, Bojana (author), Zhang, Heping (author), Zhang, Wenyi (author)

Background: The human gut hosts a diverse microbial community, essential for maintaining overall health. However, antibiotics, commonly prescribed for infections, can disrupt this delicate balance, leading to antibiotic-associated diarrhea, inflammatory bowel disease, obesity, and even neurological disorders. Recognizing this, probiotics have emerged as a promising strategy to counteract these adverse effects. Aim of review: This review aims to offer a comprehensive overview of the latest evidence concerning the utilization of probiotics in managing antibiotic-associated side effects. Key scientific concepts of review: Probiotics play a crucial role in preserving gut homeostasis, regulating intestinal function and metabolism, and modulating the host immune system. These mechanisms serve to effectively alleviate antibiotic-associated adverse effects and enhance overall well-being.

• Language: English
• Keywords: probiotics, antibiotics, gut microbiota, intestinal barrier, immune regulation, gut-brain axis
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: Str. 209-226
• Numbering: Vol. 71
• PID: 20.500.12556/RUL-169098
• UDC: 612.3:616
• ISSN on article: 2090-1224
• DOI: 10.1016/j.jare.2024.06.006
• COBISS.SI-ID: 198406403
• Publication date in RUL: 12.05.2025

Record is a part of a journal

• Title: Journal of Advanced Research
• Shortened title: J. Adv. Res.
• Publisher: Elsevier
• ISSN: 2090-1224
• COBISS.SI-ID: 524611865

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: prehrana ljudi, medicina, antibiotiki, probiotiki