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Uporaba mikroreologije za biokemijske aplikacije
ID Mulec, Matevž (Author), ID Ambrožič, Rok (Mentor) More about this mentor... This link opens in a new window

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Abstract
Mikroreologija preučuje karakterizacijo reoloških lastnosti materialov na mikro in nano nivoju, zato omogoča natančno manipulacijo in analizo tekočih in poltrdih vzorcev. Prednost mikroreologije v primerjavi s klasično reologijo je izvedba analize z manjšo količino vzorca in karakterizacija občutljivih bioloških komponent. Uporaba mikroreologije v biokemijskih aplikacijah se osredotoča na razvoj novih bioloških materialov, farmacevtskih izdelkov in raznih metodologij za analizo in karakterizacijo bioloških molekul na ekonomičen in inovativen način. V diplomskem delu sem preučil posamezne instrumente in metode za detekcijo in kvantifikacijo reoloških parametrov na mikroskopski skali. Raziskava bo še dodatno osvetlila implementacijo mikroreološke tehnike za izboljšanje raziskovalnih in proizvodnih procesov v industrijskih sektorjih, kot je to na primer farmacevtska industrija. Pri tem sem kot končni primer uporabe raziskal možnost neinvazivne detekcije proteinskih agregatov na osnovi mikroreoloških meritev.

Language:Slovenian
Keywords:Mikroreologija, biokemija, industrija.
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2025
PID:20.500.12556/RUL-167750 This link opens in a new window
COBISS.SI-ID:229054467 This link opens in a new window
Publication date in RUL:10.03.2025
Views:402
Downloads:145
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Secondary language

Language:English
Title:Innovations in microrheology for biochemical applications
Abstract:
Microreology investigates the characterization of the rheological properties of materials on the micro- and nano-levels, thus enabling precise manipulation and analysis of liquid and semi-solid samples. The advantage of microreology over classical rheology lies in its ability to perform analysis with smaller sample quantities and to characterize sensitive biological components. The application of microreology in biochemical applications focuses on the development of new biological materials, pharmaceutical products, and various methodologies for the analysis and characterization of biological molecules in an economical and innovative manner. In my thesis, I examine various instruments and methods for the detection and quantification of rheological parameters at the microscopic scale. The research will further illuminate the implementation of microreological techniques to improve research and production processes in industrial sectors, such as the pharmaceutical industry. As a case study, I explore the potential for the non-invasive detection of protein aggregates based on microreological measurements.

Keywords:Microrheology, biochemistry, industry.

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