Effect of PCSK9 inhibitors on regulators of lipoprotein homeostasis, inflammation and coagulation

Lunar, Patricija (author), Meglič, Hana (author), Vehar, Mateja (author), Ugovšek, Sabina (author), Rehberger Likozar, Andreja (author), Šebeštjen, Miran (author), Zupan, Janja (author)

Background: PCSK9 inhibitors (PCSK9i) represent a newer form of atherosclerosis treatment. Inflammation and haemostasis are key processes in the development of atherosclerosis. In this study, we investigated the influence of therapy with PCSK9i in patients with coronary artery disease (CAD) on regulators for lipoprotein homeostasis, inflammation and coagulation. Methods: Using quantitative polymerase chain reaction (qPCR), we measured the expression of the genes involved in lipoprotein homeostasis, namely for sterol regulatory element-binding protein 1 (SREBP1), SREBP2, low-density lipoprotein receptor (LDLR), hepatic lipase type C (LIPC), LDLR-related protein 8 (LRP8), and the genes associated with inflammation and coagulation, such as cluster of differentiation (CD) 36 (CD36), CD63, and CD14 in 96 patients with CAD and 25 healthy subjects. Results: Significant differences in the expression of the investigated genes between patients and healthy controls were found. Treatment with PCSK9i also resulted in significant changes in the expression of all studied genes. Conclusions: We established that PCSK9i may have a significant effect on the gene expression of lipid regulators, inflammatory markers, and coagulation parameters, independent of their lipolytic effect.

• Language: English
• Keywords: PCSK9 inhibitors, lipid regulators, inflammation, coagulation, coronary artery disease
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy; MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2025
• Number of pages: 15 str.
• Numbering: Vol. 13, issue 2, [article no.] 294
• PID: 20.500.12556/RUL-167041
• UDC: 616-002:616.132.2
• ISSN on article: 2227-9059
• DOI: 10.3390/biomedicines13020294
• COBISS.SI-ID: 224843267
• Publication date in RUL: 05.02.2025

Record is a part of a journal

• Title: Biomedicines
• Shortened title: Biomedicines
• Publisher: MDPI
• ISSN: 2227-9059
• COBISS.SI-ID: 523006745

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: zaviralci PCSK9, regulatorji lipidov, koagulacija, bolezen koronarnih arterij, vnetje, koronarne arterije