Serum cortisol and blood glucose concentrations in anesthetized dogs administered levobupivacaine and low-dose dexmedetomidine for regional anesthesia of the oral cavity

Pavlica, Matic (author), Kržan, Mojca (author), Nemec, Ana (author), Nemec, Marija (author), Baš, Anže (author), Kosjek, Tina (author), Seliškar, Alenka (author)

The effects on the stress response, postanesthetic sedation, and altered behavior were evaluated following regional anesthesia and dental treatment in 40 dogs. Serum cortisol and blood glucose concentrations were measured following the administration of levobupivacaine (LBUP) 0.5% and dexmedetomidine (DEX) (0.5 μg/kg) or a placebo. The dogs were randomly assigned to 4 groups of 10 dogs each. All dogs received a regional nerve block using LBUP 0.5%. Group 1 (LBUP + DEX IV) also received DEX intravenously (IV); group 2 (LBUP + PLC IV) also received a placebo IV; group 3 (LBUP + DEX IO) also received DEX in one infraorbital (IO) block; and group 4 (LBUP + DEX IA) also received DEX in one inferior alveolar (IA) block. Serum cortisol and blood glucose concentrations were determined before the administration of oral blocks and at the end of the procedure. Sedation and behavior scores were assessed before premedication and hourly for 6 h after the end of anesthesia. Cortisol con- centration did not change in any group at either evaluation time. The glucose concentration was higher (P < .05) only in the LBUP + DEX IA group at the end of the procedure. The sedation score was higher until the end of the observation period only in the LBUP + DEX IV and LBUP + PLC IV groups. No change in behavior score was observed in any of the groups. The reduction of perioperative stress response in all groups was due to the use of LBUP and not DEX.

• Language: English
• Keywords: bupivacaine, dental pain, dexmedetomidine, extractions, levobupivacaine, oral cavity, perioperative stress, regional anesthesia, regionalnerve blocks, dogs
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: VF - Veterinary Faculty; MF - Faculty of Medicine; PEF - Faculty of Education
• Publication version: Author Accepted Manuscript
• Year: 2025
• Number of pages: Str. 66-74
• Numbering: Vol. 42, no. 1
• PID: 20.500.12556/RUL-166743
• UDC: 636.09:616.31
• ISSN on article: 0898-7564
• DOI: 10.1177/08987564241270598
• COBISS.SI-ID: 204664579
• Publication date in RUL: 23.01.2025

Record is a part of a journal

• Title: Journal of veterinary dentistry
• Shortened title: J. vet. dent.
• Publisher: the American Veterinary Dental Society
• ISSN: 0898-7564
• COBISS.SI-ID: 872468