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Alkiliranje β-keto estra na osnovi glicina
ID Kobler, Andraž (Author), ID Grošelj, Uroš (Mentor) More about this mentor... This link opens in a new window

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Abstract
Diplomska naloga obravnava sintezo izhodnega β-keto estra na osnovi Boc-zaščitenega glicina in njegovo nadaljnjo funkcionalizacijo z alkiliranjem in Michaelovo adicijo. Pri uporabi različnih organokatalizatorjev, vključno s kiralnimi skvaramidnimi katalizatorji, je bila dosežena visoka enantioselektivnost študirane pretvorbe, kar je omogočilo pridobitev enantiomerno obogatenih produktov. Raziskava je temeljila na uporabi analitičnih metodah, kot so NMR, IR in HPLC, za določitev strukture in čistosti sintetiziranih spojin. Dobljeni rezultati kažejo potencial uporabljenih katalizatorjev pri sintezi kompleksnih molekul.

Language:Slovenian
Keywords:β-keto estri, organokataliza, alkiliranje, Michaelova adicija, kiralni katalizatorji
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2025
PID:20.500.12556/RUL-166295 This link opens in a new window
COBISS.SI-ID:222855427 This link opens in a new window
Publication date in RUL:06.01.2025
Views:402
Downloads:390
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Secondary language

Language:English
Title:Alkylation of glycine-derived β-keto ester
Abstract:
The thesis investigates the synthesis of the starting β-keto ester derived from Boc-protected glycine and its subsequent functionalization through alkylation and Michael addition. The use of various organocatalysts, including chiral squaramide catalysts, resulted in high enantioselectivity, enabling the formation of enantiomerically enriched products. The study employed analytical techniques such as NMR, IR, and HPLC to determine the structure and purity of the synthesized compounds. The results highlight the potential of the applied catalysts for the synthesis of complex molecules.

Keywords:β-keto esters, organocatalysis, alkylation, Michael addition, chiral catalysts

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