Novel strategies in systemic and local administration of therapeutic monoclonal antibodies

Prašnikar, Monika (author), Bjelošević Žiberna, Maja (author), Gosenca Matjaž, Mirjam (author), Ahlin Grabnar, Pegi (author)

Monoclonal antibodies (mAbs) are an evolving class of biopharmaceuticals, with advancements evident across various stages of their development. While discovery, mAb chemical optimization, production and purification processes have been thoroughly reviewed, this paper aims to offer a summary of novel strategies in administration of mAbs. At present, systemic delivery of mAbs is available through parenteral administration routes with focus on subcutaneous administration. In addition, oriented toward patient-friendly therapy, other less invasive administration routes of mAbs, such as inhalation, nasal, transdermal, and oral administration, are explored. Literature data reveals the potential for local delivery of mAbs via inhalation, nasal, transdermal, intratumoral, intravitreal and vaginal administration, offering high efficacy with fewer systemic adverse effects. However, to date, only mAb medicines are available for intravitreal administration, mainly due to higher bioavailability, and an intranasal spray is authorised as a medical device. The review highlights the promising data in approval of novel administration routes, likely through inhalation, but further intensive research considering the current obstacles, is essential.

• Language: English
• Keywords: biopharmaceuticals, monoclonal antibodies, delivery systems, patient-friendly therapy, subcutaneous administration
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: FFA - Faculty of Pharmacy
• Publication status: Published
• Publication version: Version of Record
• Year: 2024
• Number of pages: 13 str.
• Numbering: Vol. 667, pt. A, art. 124877
• PID: 20.500.12556/RUL-164601
• UDC: 615.015.14
• ISSN on article: 0378-5173
• DOI: 10.1016/j.ijpharm.2024.124877
• COBISS.SI-ID: 213575427
• Publication date in RUL: 05.11.2024

Record is a part of a journal

• Title: International journal of pharmaceutics
• Shortened title: Int. j. pharm.
• Publisher: Elsevier
• ISSN: 0378-5173
• COBISS.SI-ID: 3087631

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: biofarmacevtski izdelki, monoklonska protitelesa, pacientu prijazna terapija, subkutana aplikacija, dostavni sistemi

Projects

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: P1-0189
• Name: Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih

• Funder: ARIS - Slovenian Research and Innovation Agency
• Project number: L1-3160
• Name: Razvoj visokokoncentriranih proteinskih formulacij in vrednotenje kinetike absorpcije po subkutani aplikaciji