Introduction: Weakness of the quadriceps femoris muscle is usually observed after traumatic injuries and surgical procedures on the knee joint. The lack of muscle activation is attributed to arthrogenic muscle inhibition, a process that prevents full muscle activation due to neuromuscular inhibition and contributes to muscle atrophy. Low-load resistance exercise with blood flow restriction (ischemic exercise) have been shown to improve muscle strength in individuals with knee joint injuries, as they appear to be particularly useful when large mechanical loads on the joint are contraindicated. Purpose: The aim of the study was to investigate the effect of ischemic exercises in patients with knee joint injuries, focusing on the subjective assessment of knee joint function and pain sensation around the knee joint. Methods: Patients were divided into an ischemic group and a placebo group. The training program to strengthen the quadriceps femoris muscle was carried out for four weeks with three training sessions per week. The ischemic group trained with obstructed blood flow through the active muscles caused by an inflatable cuff, while the placebo group trained without blood flow obstruction. Before and after the training program, the patients evaluated the function of the knee joint using the Lysholm questionnaire. The intensity of knee pain was systematically assessed by the patients during the training program using a numerical scale. Results: In the ischemic group, no significant (p = 0.359) improvement in the subjective assessment of knee joint function (6.8 %) was achieved by the exercise program, while it improved significantly (p < 0.001) by 17 % in the placebo group. We found no significant differences in pain intensity between the ischemic and placebo groups during the training program. Discussion and conclusion: Subjective assessment of knee joint function improved in both groups, but the improvement was greater in the placebo group. Our results do not confirm our original hypothesis that ischemic exercises cause a greater improvement in the subjective assessment of knee joint function and the perception of pain in the knee joint region than standard training of the same intensity. Further studies with better methodology are needed.
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