Introduction: The face proportionally represents only a small part of the body. It is one of the main factors of social identity and one of the main tools for interpersonal communication. The loss of teeth significantly affects the anatomical and aesthetic changes of the face/oral cavity. For a long time, prosthetics addressed this issue mainly by making complete dentures. In cases where the anatomy of the patient's resorbed jaw does not provide stabilization of the prosthesis, we can decide for implant prosthetics. The main goals of resolving complete edentulism with implants are either replacing removable dentures with a fixed prosthesis on implants or stabilizing the removable denture on implants. Purpose: The purpose of the diploma work is to review the existing literature on the problem of edentulism and to describe possible solutions to this problem, focusing mainly on implant prosthetic and to describe in more detail a fixed screw retained construction on four dental implants. The results of the thesis describe the process of manufacturing a metal-composite all-on-four construction, made by combining digital and analogue technology. Methods: A descriptive research method was used in the theoretical part of the diploma work. The main sources of information were the articles in scientific journals and professional books. The literature was searched in libraries and bibliographic databases Google Scholar, Cobiss, PubMed, and other. In the practical part of the diploma work, we made a metal-composite screw retained bridge prosthesis in the laboratory by using digital and analogue technology. Results: A metal-composite fixed screw bridge structure on four implants was made. The process itself is based on the transfer of a digitally produced prototype to the final product, which was produced using the injection composite technique on a digitally produced CoCr construction. The manufacturing process varies between digital and analogue techniques. Discussion and conclusion: The concept of a screw retained bridge construction on four implants, or in other words, all-on-four, is a very successful method of treating edentulous patients with excellent clinical results. Due to the reduction in the number of implants and components, this type of construction enables a reduction in costs compared to traditional reconstructions on implants.
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