Your browser does not allow JavaScript!
JavaScript is necessary for the proper functioning of this website. Please enable JavaScript or use a modern browser.
Open Science Slovenia
Open Science
DiKUL
slv
|
eng
Search
Browse
New in RUL
About RUL
In numbers
Help
Sign in
Modeling the effect of red blood cells deformability on blood flow conditions in human carotid artery bifurcation
ID
Urevc, Janez
(
Author
),
ID
Žun, Iztok
(
Author
),
ID
Brumen, Milan
(
Author
),
ID
Štok, Boris
(
Author
)
PDF - Presentation file,
Download
(5,09 MB)
MD5: 7E4F9EF00B1F5EAF90D1DC505D043E08
URL - Source URL, Visit
https://asmedigitalcollection.asme.org/biomechanical/article-abstract/139/1/011011/371365/Modeling-the-Effect-of-Red-Blood-Cells?redirectedFrom=fulltext
Image galllery
Abstract
The purpose of this work is to predict the effect of impaired red blood cells (RBCs) deformability on blood flow conditions in human carotid artery bifurcation. First, a blood viscosity model is developed that predicts the steady-state blood viscosity as a function of shear rate, plasma viscosity, and mechanical (and geometrical) properties of RBC's. Viscosity model is developed by modifying the well-known Krieger and Dougherty equation for monodisperse suspensions by using the dimensional analysis approach. With the approach, we manage to account for the microscopic properties of RBC's, such as their deformability, in the macroscopic behavior of blood via blood viscosity. In the second part of the paper, the deduced viscosity model is used to numerically predict blood flow conditions in human carotid artery bifurcation. Simulations are performed for different values of RBC's deformability and analyzed by investigating parameters, such as the temporal mean wall shear stress (WSS), oscillatory shear index (OSI), and mean temporal gradient of WSS. The analyses show that the decrease of RBC's deformability decrease the regions of low WSS (i.e., sites known to be prevalent at atherosclerosis-prone regions); increase, in average, the value of WSS along the artery; and decrease the areas of high OSI. These observations provide an insight into the influence of blood's microscopic properties, such as the deformability of RBC's, on hemodynamics in larger arteries and their influence on parameters that are known to play a role in the initiation and progression of atherosclerosis.
Language:
English
Keywords:
blood viscosity model
,
non-Newtonian fluids
,
blood flow
,
computational fluid dynamics
,
biomechanics
,
bifurcation
,
blood
,
carotid arteries
,
hemorheology
,
modeling
,
shear rate
,
viscosity
,
flow
,
dynamics
,
hemodynamics
,
particulate matter
,
shear stress
,
erythrocytes
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FS - Faculty of Mechanical Engineering
Publication status:
Published
Publication version:
Author Accepted Manuscript
Year:
2017
Number of pages:
11 str.
Numbering:
Vol. 139, iss. 1, art. 011011
PID:
20.500.12556/RUL-160784-6746e440-d809-7c69-0ddf-695251a79579
UDC:
532:616.13(045)
ISSN on article:
0148-0731
DOI:
10.1115/1.4035122
COBISS.SI-ID:
15115291
Publication date in RUL:
04.09.2024
Views:
92
Downloads:
34
Metadata:
Cite this work
Plain text
BibTeX
EndNote XML
EndNote/Refer
RIS
ABNT
ACM Ref
AMA
APA
Chicago 17th Author-Date
Harvard
IEEE
ISO 690
MLA
Vancouver
:
Copy citation
Share:
Record is a part of a journal
Title:
Journal of biomechanical engineering
Shortened title:
J. biomech. eng.
Publisher:
American Society of Mechanical Engineers
ISSN:
0148-0731
COBISS.SI-ID:
6758149
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
model viskoznosti krvi
,
tok krvi
,
nenewtonske tekočine
,
računalniška dinamika tekočin
,
mehanika tekočin
Projects
Funder:
ARRS - Slovenian Research Agency
Project number:
P2-0162
Name:
Tranzientni dvofazni tokovi
Funder:
ARRS - Slovenian Research Agency
Project number:
L3-2319
Name:
Morfološke spremembe notranje karotidne arterije po vstavitvi žilne opornice
Similar documents
Similar works from RUL:
Similar works from other Slovenian collections:
Back