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Maternal APOE ε2 as a possible risk factor for elevated prenatal Pb levels
ID Palir, Neža (Author), ID Marc, Janja (Author), ID Falnoga, Ingrid (Author), et al.

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Abstract
Lead (Pb) is a global contaminant associated with multiple adverse health effects. Humans are especially vulnerable during critical developmental stages. During pregnancy, exposure to Pb can occur through diet and release from maternal bones. Apolipoprotein E gene (APOE) variants (ɛ2, ɛ3, ɛ4 alleles) may influence sex steroid hormones, bone metabolism, and Pb kinetics. We examined the interplay among maternal APOE (mAPOE) genotypes, fetal sex, parity, and Pb in maternal and cord blood (mB-Pb, CB-Pb) using linear regression models. Our study involved 817 pregnant women and 772 newborns with measured adequate levels of zinc and selenium. We compared carriers of the ε2 and ε4 alleles to those with the ε3/ε3 genotype. The geometric means (range) of mB-Pb and CB-Pb were 11.1 (3.58–87.6) and 9.31 (1.82–47.0) ng/g, respectively. In cases with female fetuses, the maternal mAPOE ε2 allele was associated with higher, while the mAPOE ε4 allele was associated with lower mB-Pb and CB-Pb levels. Nulliparity increased the strength of the observed associations. These findings highlight the significance of mAPOE genetics, fetal sex, and parity in prenatal Pb kinetics. Notably, the maternal ε2 allele may increase the risk of Pb exposure.

Language:English
Keywords:cord blood, maternal APOE ε2 allele, bone turnover, fetal sex, parity, lead, blood
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:FFA - Faculty of Pharmacy
Publication status:Published
Publication version:Version of Record
Year:2024
Number of pages:12 str.
Numbering:Vol. 260, art. 119583
PID:20.500.12556/RUL-159802 This link opens in a new window
UDC:504.5
ISSN on article:1096-0953
DOI:10.1016/j.envres.2024.119583 This link opens in a new window
COBISS.SI-ID:202005507 This link opens in a new window
Publication date in RUL:25.07.2024
Views:161
Downloads:50
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Record is a part of a journal

Title:Environmental research
Shortened title:Environ. res.
Publisher:Elsevier
ISSN:1096-0953
COBISS.SI-ID:512760888 This link opens in a new window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.

Secondary language

Language:Slovenian
Keywords:popkovna kri, plodov spol, polimorfizmi, svinec, kri, nosečnost, fetus

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P1-0143
Name:Kroženje snovi v okolju, snovna bilanca in modeliranje okoljskih procesov ter ocena tveganja

Funder:ARRS - Slovenian Research Agency
Project number:J7-9400
Name:Nevropsihološke disfunkcije, ki jih povzroča nizka stopnja izpostavljenosti izbranim onesnaževalom iz okolja pri občutljivi populaciji - NEURODYS

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