Sustainable furfural valorization : screening amine transaminases and amine donors for efficient furfurylamine synthesis : research data underlying the article

Božinović, Marko (author), Jereb, Marjan (author), Šketa, Borut (author), Gaber, Aljaž (author), Seručnik, Mojca (author), Košmrlj, Janez (author), Žnidaršič Plazl, Polona (author)

The growing global demand for furfurylamine (FA) underscores the need for environmentally friendly production methods. To address this, we explored a biocatalytic approach using transaminase (TA) for furfural (FUR) amination. Our main goal was to find an effective enzyme and cost-efficient amine donor for FA production. Screening various enzymes and amine donors revealed that FA synthesis occurred only with a tetrameric $N$-His$_6$-ATA-wt enzyme and ($S$)-(−)-α-methylbenzylamine (MBA) as the amine donor at equimolar concentrations. This method yielded 96% FA in 30 minutes, the highest reported efficiency. The proposed reaction operates at 30°C with minimal energy and material consumption, offering a promising sustainable route for FA synthesis.

• Language: English
• Keywords: furfural, furfurylamine, transaminase, biomass valorization, green chemistry
• Typology: 2.20 - Complete scientific database of research data
• Organization: FKKT - Faculty of Chemistry and Chemical Technology
• Year: 2024
• PID: 20.500.12556/RUL-159748
• Data col. methods: Measurements and tests
• Publication date in RUL: 22.07.2024
• Collection: This document is a collection and includes 1 document.

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: furfural, furfurilamin, transaminaze, valorizacija biomase, zelena kemija