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Razvoj antimikrobnih hidrogelov hitozana z uporabo mikrofluidne tehnologije
ID Mihelič, Vita (Author), ID Ambrožič, Rok (Mentor) More about this mentor... This link opens in a new window

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Abstract
Funkcionalizirani polimeri, kamor spada tudi hidrogel iz hitozana, modificiran s kateholom, postajajo vedno bolj zanimivi in aktualni. Hitozan je bioaktiven, netoksičen in okolju prijazen polimer z antibakterijskimi lastnostmi. Poleg tega se ga da enostavno modificirati, zato je primeren za številne aplikacije na različnih področjih. Lastnosti hitozana omogočajo pH odvisno sol-gel pretvorbo, preko katere pride do nastanka hidrogelne mreže. Ta mehanizem se lahko izkoristi za elektrodepozicijo hitozana na elektro prevoden substrat. Hidrogel je lahko dodatno modificiran s kateholom, naravnim adhezivnim proteinom. Modifikacija poteka kemijsko ali elektro-kemijsko z anodno oksidacijo. Na hidrogel vezani kateholi se oksidirajo in kot stranski produkt se tvorijo aktivne kisikove zvrsti, kot je na primer vodikov peroksid. Aktivne vodikove zvrsti se lahko uporabijo za degradacijo organskih onesnaževal, v mikrosistemu pripravljene hidrogele pa kot antimikrobne hidrogele.

Language:Slovenian
Keywords:hitozan, katehol, hidrogel, antimikrobnost, mikrofluiden sistem
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Technology
Year:2024
PID:20.500.12556/RUL-159152 This link opens in a new window
COBISS.SI-ID:202777603 This link opens in a new window
Publication date in RUL:02.07.2024
Views:268
Downloads:74
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Secondary language

Language:English
Title:Development of antimicrobial hydrogel films from chitosan using microfluidic technology
Abstract:
Functionalized polymers, such as catechol-modified chitosan hydrogel, are becoming increasingly interesting and relevant. Chitosan is a bioactive, non-toxic, and environmentally friendly polymer with antibacterial properties. Additionally, it can be easily modified, making it suitable for a wide range of applications in various fields. The properties of chitosan allow for a pH-dependent sol-gel conversion, forming a hydrogel network. This mechanism can be utilized to electrodeposit chitosan onto an electrically conductive substrate. The hydrogel can be further enhanced with catechol, a natural adhesive protein, through chemical modification or electrochemical anodic oxidation. When catechols are bound to the hydrogel and oxidized, active oxygen species such as hydrogen peroxide are produced as by-products. These active oxygen species can be used to degrade organic pollutants, and the hydrogels prepared in this microsystem can serve as antimicrobial hydrogels.

Keywords:chitosan, catechol, hydrogel, antimicrobial, microfluidic system

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