Pregled anorganskih spojin v tekočih kozmetičnih izdelkih na slovenskem tržišču

Erjavec, Pia (author), Obreza, Aleš (mentor)

V diplomski nalogi smo proučili vsebnost anorganskih snovi v 50 naključno izbranih tekočih kozmetičnih izdelkih na slovenskem tržišču. Namen je bil ugotoviti, katere snovi se uporabljajo najpogosteje in katero funkcijo opravljajo v kozmetičnih izdelkih. Petim naključno izbranim anorganskim snovem smo določili toksikološki profil oz. oceno varnosti. Te sestavine so titanov dioksid, aluminijev klorohidrat, železovi hidroksidi in oksidi, silicijev dioksid in smukec. Izbrane izdelke smo razporedili v različne skupine kozmetičnih izdelkov (dekorativna kozmetika, izdelki za nego in čiščenje obraza, nego trepalnic in obrvi, čiščenje rok, proti znojenju, za zaščito pred soncem, negovanje in čiščenje ustne votline ter nego las). Največje število anorganskih snovi v izdelku je bilo 17, najmanjše pa 2. Če je izdelek vseboval le eno anorgansko snov, smo ga iz nabora izločili. Pri pregledu smo opazili, da je v naboru izdelkov prisotnih 41 anorganskih snovi. Najpogosteje prisotna anorganska snov je bila voda (v 41 izdelkih, kar je 82 % vseh izbranih izdelkov), ki se najpogosteje uporablja kot topilo, ali pa se uporablja v procesu njihove izdelave, zato je nismo vključili v diplomsko delo. Sledijo ji titanov dioksid, ki je bil prisoten v 15 izdelkih, disteardimonijev hektorit v 13 izdelkih, železovi oksidi in hidroksidi v 12 izdelkih, dinatrijev edetat v 11 izdelkih ter natrijev klorid v 10 izdelkih. Vse anorganske snovi smo s pomočjo podatkovne baze CosIng razdelili v skupine glede na njihove funkcije. Več snovi ima lahko več različnih funkcij, zato smo pri porazdelitvi skušali upoštevati njihovo glavno funkcijo. Petim sestavinam smo določili še toksikološki profil oz. oceno varnosti. Ta nabor je bil naključen in ni bil povezan s pogostostjo pojavljanja v kozmetičnih izdelkih. Titanov dioksid smo zasledili v 15 kozmetičnih izdelkih (30 % vseh KI), aluminijev klorohidrat v 3 (6 %), železove hidrokside in okside v 12 (24 %), silicijev dioksid v 8 (16 %), smukec pa v 2 (4 %). Pri celotnem pregledu anorganskih sestavin smo opazili, da so te v kozmetičnih izdelkih netoksične za uporabo, če se nahajajo znotraj priporočenih koncentracij in se nanašajo na nepoškodovano kožo. Pri tem lahko obstajajo drugačne omejitve, če se sestavine nahajajo v kozmetičnih izdelkih, namenjenim otrokom ali za uporabo okoli oči in na predelih sluznic.

• Language: Slovenian
• Keywords: tekoči kozmetični izdelki, anorganske snovi, ocena varnosti
• Work type: Bachelor thesis/paper
• Organization: FFA - Faculty of Pharmacy
• Year: 2024
• PID: 20.500.12556/RUL-158834
• Publication date in RUL: 21.06.2024

Secondary language

• Language: English
• Title: Review of inorganic compounds in liquid cosmetic products on the Slovenian market

Abstract

In the thesis, the inorganic compounds of 50 randomly selected liquid cosmetic products from the Slovenian market were studied. The aim was to identify the most often used ingredients and their purposes in cosmetic products. Five inorganic compounds that were chosen at random were given a safety evaluation or toxicological profile. These components include titanium dioxide, aluminum hydroxide, iron oxides, silica and talc. The selected products were grouped into different categories of cosmetic products (decorative cosmetics, facial care and cleansing, eyelash and eyebrow care, hand cleansing, antiperspirants, sunscreens, oral care and cleansing, and hair care). The maximum number of inorganic substances in a product is 17, the minimum number is 2. A product was eliminated from the set if it only contained one inorganic component. Upon closer inspection, we found that the product range included 41 inorganic chemicals. Water was the most prevalent inorganic ingredient of cosmetic products (in 41 cosmetic products, which is 82 % of all chosen products), used as a solvent or in the manufacturing process, and is not included in the thesis. It is followed by titanium dioxide, which appears in 15 cosmetic products, disteardimonium hectorite in 13, iron oxides and hydroxides in 12, disodium edetate in 11, and sodium chloride in 10. With the help of the CosIng database, we distributed all inorganic substances into groups according to their functions. Several inorganic compounds may have multiple roles, thus we attempted to incorporate them in groups according to their primary purpose. We also assessed the toxicological profile and safety evaluation for five inorganic compounds. Our selection of ingredients was arbitrary and has nothing to do with how frequently they appear in the selected cosmetic products. Titanium dioxide was found in 15 cosmetic products (30 % of all chosen products), aluminium chlorohydrate in 3 (6 %), iron oxides in 12 (24 %), silica in 8 (16 %), talc in 2 (4 %). In our overall review of inorganic ingredients, we have observed that when used at recommended dosages and applied on intact skin, they demonstrate non-toxic properties in cosmetic products. It should be noted that the regulatory restrictions may vary depending on whether the substances are utilized in cosmetic products intended for use on children or around the eyes and mucous membranes.

• Keywords: liquid cosmetic products, inorganic compounds, safety assesment