In my thesis, I explored synthetic approaches for the preparation of N-substituted 2-phenylimidazoles. Additionally, I provided examples of the synthesis of imidazole derivatives. I examined the reaction conditions that allow for the successful introduction of substituents on the nitrogen atom in imidazole. Using bases such as NaOH or KOH, I carried out deprotonation on the nitrogen atom in 2-phenylimidazole and subsequently introduced various groups at this position. I introduced benzyl, butyl, methyl, and ethyl groups on the nitrogen atom. The compounds I used were benzyl bromide, 1-bromobutane, methyl iodide, and 1,2-dichloroethane. By employing different synthetic approaches, I obtained various products, which I purified and determined their structures using spectroscopic methods ($^1$H NMR, IR, HRMS). I discovered that higher temperatures increase the rate of the chemical reaction. However, in all cases, I did not achieve a positive result, meaning I did not synthesize the desired product.
|
