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Modelling how curved active proteins and shear flow pattern cellular shape and motility
ID
Sadhukhan, Shubhadeep
(
Author
),
ID
Penič, Samo
(
Author
),
ID
Iglič, Aleš
(
Author
),
ID
Gov, Nir S.
(
Author
)
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https://www.frontiersin.org/articles/10.3389/fcell.2023.1193793/full
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Abstract
Cell spreading and motility on an adhesive substrate are driven by the active physical forces generated by the actin cytoskeleton. We have recently shown that coupling curved membrane complexes to protrusive forces, exerted by the actin polymerization that they recruit, provides a mechanism that can give rise to spontaneous membrane shapes and patterns. In the presence of an adhesive substrate, this model was shown to give rise to an emergent motile phenotype, resembling a motile cell. Here, we utilize this “minimal-cell” model to explore the impact of external shear flow on the cell shape and migration on a uniform adhesive flat substrate. We find that in the presence of shear the motile cell reorients such that its leading edge, where the curved active proteins aggregate, faces the shear flow. The flow-facing configuration is found to minimize the adhesion energy by allowing the cell to spread more efficiently over the substrate. For the non-motile vesicle shapes, we find that they mostly slide and roll with the shear flow. We compare these theoretical results with experimental observations, and suggest that the tendency of many cell types to move against the flow may arise from the very general, and non-cell-type-specific mechanism predicted by our model.
Language:
English
Keywords:
cell motility
,
cytoskeleton
,
shear flow
,
adhesion
,
curved membrane protein
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FE - Faculty of Electrical Engineering
Publication status:
Published
Publication version:
Version of Record
Publication date:
31.05.2023
Year:
2023
Number of pages:
Str. 1-10
Numbering:
Vol. 11, [article no.] 1193793
PID:
20.500.12556/RUL-155438
UDC:
577
ISSN on article:
2296-634X
DOI:
10.3389/fcell.2023.1193793
COBISS.SI-ID:
154483715
Publication date in RUL:
02.04.2024
Views:
346
Downloads:
79
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Record is a part of a journal
Title:
Frontiers in cell and developmental biology
Shortened title:
Front. cell dev. biol.
Publisher:
Frontiers Media S.A.
ISSN:
2296-634X
COBISS.SI-ID:
523093529
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
Description:
This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Secondary language
Language:
Slovenian
Keywords:
mobilnost celice
,
citoskeleton
,
strižni tok
,
adhezija
,
ukrivljenost proteinov v membrani
Projects
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
J2-4447-2022
Name:
Vpliv mehanike in topologije membrane na celično ujetje bakterij, virionov in anorganskih delcev
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
J3-3066-2021
Name:
Optimizacija s trombociti in zunajceličnimi vezikli bogate avtologne krvne plazme za zdravljenje pooperativnih ran v otorinolaringologiji
Funder:
ARIS - Slovenian Research and Innovation Agency
Project number:
P2-0232-2022
Name:
Analiza biomedicinskih slik in signalov
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