The role of isoflavones in the prevention of breast cancer and prostate cancer

Pejčić, Tomislav (author), Zeković, Milica (author), Bumbaširević, Uroš (author), Kalaba, Milica (author), Vovk, Irena (author), Bensa, Maja (author), Popović, Lazar (author), Tešić, Živoslav (author)

This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER).

• Language: English
• Keywords: isoflavones, breast cancer, prostate cancer
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: ZF - Faculty of Health Sciences
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 27 str.
• Numbering: Vol. 12, iss. 2, art. 368
• PID: 20.500.12556/RUL-155399
• UDC: 616
• ISSN on article: 2076-3921
• DOI: 10.3390/antiox12020368
• COBISS.SI-ID: 142086147
• Publication date in RUL: 29.03.2024

Record is a part of a journal

• Title: Antioxidants
• Shortened title: Antioxidants
• Publisher: MDPI
• ISSN: 2076-3921
• COBISS.SI-ID: 522976025

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: medicina, bolezni, rakava obolenja, epidemiološke študije, rak dojke, rak prostate, hrana