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Preliminary investigation of organ-protective effects of fullerenol in vivo in acute toxicity during doxorubicin therapy in healthy pigs
ID
Injac, Rade
(
Author
),
ID
Djordjević, Aleksandar N.
(
Author
),
ID
Štrukelj, Borut
(
Author
)
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Abstract
Objectives The potential protective effect of fullerenol [C$_{60}$(OH)$_{24}$, Frl], a strong antioxidant, was investigated at a single dose of 25 mg/kg, administered orally (per os; p.o.) and intraperitoneally (i.p.), in the liver, lung, kidney, heart and spleen of healthy pigs, prior to doxorubicin (Dox)-induced toxicity at a single i.p. dose of 10 mg/kg. Methods We used the F1 generation of an in-vivo pig model (whose parents were Swedish Landrace and Large Yorkshire) to explore whether Frl, administered 6 h for p.o. and 30 min for i.p. prior to Dox treatment, could protect organs against damage caused by oxidative stress. Key findings According to the macroscopic, haematological, biochemical and physiological results, Frl exerted a potential protective effect on all investigated organs (heart, liver, lung, spleen and kidney) in pigs after i.p. administration. However, the results from Frl p.o. administration were inconclusive, therefore warranting further investigation. Conclusions Frl at a low dose of 25 mg/kg demonstrated satisfactory organ protection against Dox-induced toxicity in healthy pigs after i.p. injection. However, additional follow-up studies in pig models of cancer and with longer Dox and Frl treatment periods would be required to further delineate the optimal and clinically relevant conditions for Frl administration.
Language:
English
Keywords:
fullerenol
,
doxorubicin
,
toxicity
,
antioxidants
,
pigs
Work type:
Article
Typology:
1.01 - Original Scientific Article
Organization:
FFA - Faculty of Pharmacy
Publication status:
Published
Publication version:
Version of Record
Year:
2024
Number of pages:
15 str.
Numbering:
Vol. 3, iss. 1, art. rqad038
PID:
20.500.12556/RUL-154824
UDC:
615
ISSN on article:
2754-5849
DOI:
10.1093/rpsppr/rqad038
COBISS.SI-ID:
186771459
Publication date in RUL:
04.03.2024
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262
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Title:
RPS pharmacy and pharmacology reports
Shortened title:
RPS pharm. pharmacol. rep.
Publisher:
Oxford University Press, Royal Pharmaceutical Society
ISSN:
2754-5849
COBISS.SI-ID:
186769923
Licences
License:
CC BY 4.0, Creative Commons Attribution 4.0 International
Link:
http://creativecommons.org/licenses/by/4.0/
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This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
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