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Improved early risk stratification of deep sternal wound infection risk after coronary artery bypass grafting
ID Kamenšek, Tina (Author), ID Kališnik, Jurij-Matija (Author), ID Ledwon, Mirek (Author), ID Santarpino, Giuseppe (Author), ID Fittkau, Matthias (Author), ID Vogt, Ferdinand (Author), ID Žibert, Janez (Author)

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Abstract
Background: Deep sternal wound infection (DSWI) following open heart surgery is associated with excessive morbidity and mortality. Contemporary DSWI risk prediction models aim at identifying high-risk patients with varying complexity and performance characteristics. We aimed to optimize the DSWI risk factor set and to identify additional risk factors for early postoperative detection of patients prone to DSWI. Methods: Single-centre retrospective analysis of patients with isolated multivessel coronary artery disease undergoing myocardial revascularization at Paracelsus Medical University Nuremberg between 2007 and 2022 was performed to identify risk factors for DSWI. Three data sets were created to examine preoperative, intraoperative, and early postoperative parameters, constituting the “Baseline”, the “Improved Baseline” and the “Extended” models. The “Extended” data set included risk factors that had not been analysed before. Univariable and stepwise forward multiple logistic regression analyses were performed for each respective set of variables. Results: From 5221 patients, 179 (3.4%) developed DSWI. The “Extended” model performed best, with the area under the curve (AUC) of 0.80, 95%-CI: [0.76, 0.83]. Pleural effusion requiring intervention, postoperative delirium, preoperative hospital stay > 24 h, and the use of fibrin sealant were new independent predictors of DSWI in addition to age, Diabetes Mellitus on insulin, Body Mass Index, peripheral artery disease, mediastinal re-exploration, bilateral internal mammary harvesting, acute kidney injury and blood transfusions. Conclusions: The “Extended” regression model with the short-term postoperative complications significantly improved DSWI risk discrimination after surgical revascularization. Short preoperative stay, prevention of postoperative delirium, protocols reducing the need for evacuation of effusion and restrictive use of fibrin sealant for sternal closure facilitate DSWI reduction.

Language:English
Keywords:coronary artery bypass grafting, deep sternal wound infection, risk assessment
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:ZF - Faculty of Health Sciences
MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2024
Number of pages:11 str.
Numbering:Vol. 19, art. 93
PID:20.500.12556/RUL-154756 This link opens in a new window
UDC:616.12-089
ISSN on article:1749-8090
DOI:10.1186/s13019-024-02570-9 This link opens in a new window
COBISS.SI-ID:187099907 This link opens in a new window
Publication date in RUL:29.02.2024
Views:601
Downloads:57
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Record is a part of a journal

Title:Journal of cardiothoracic surgery
Publisher:BioMed Central
ISSN:1749-8090
COBISS.SI-ID:3053332 This link opens in a new window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Language:Slovenian
Keywords:koronarna arterijska obvodnica, globoka okužba prsnice, ocena tveganja

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