Prehranski status pri ženskah v postopku zunajtelesne oploditve

Trampuš, Lana (author), Benedik, Evgen (mentor), Pinter, Bojana (co-mentor)

Potrebno je boljše razumevanje potencialnih spremenljivih dejavnikov tveganja z vplivom na uspešnost oploditve z biomedicinsko pomočjo, kot so življenjski slog, telesna sestava, prehranske navade in preskrbljenost z mikrohranili. Namen magistrske naloge je bilo preveriti stanje prehranjenosti, prehranskih navad, življenjskega sloga in preskrbljenosti z vitaminom B9, vitaminom B12 in vitaminom D pri ženskah pred postopkom zunajtelesne oploditve (ZTO) v Sloveniji. V raziskavo smo vključili 69 prostovoljk, ki so med januarjem 2023 in marcem 2023 prvič obiskale ambulanto za začetek postopka ZTO na Ginekološki kliniki, Univerzitetnega kliničnega centra Ljubljana. Podatke smo pridobili z meritvijo telesne mase, oceno telesne sestave z bioimpedančnim analizatorjem BIA 101 in z vprašalnikom o sociodemografskem statusu, prehranskih navadah, pogostosti uživanja živil v preteklem letu, uživanju prehranskih dopolnil, izkušnjami s kajenjem ter z vprašanji o telesni dejavnosti. Poleg tega je bil udeleženkam odvzet vzorec venske krvi za biokemijske laboratorijske preiskave (vitamin B9, vitamin B12, vitamin D) v laboratoriju Kliničnega inštituta za klinično kemijo in biokemijo, Univerzitetnega kliničnega centra Ljubljana. Prehrana udeleženk pri večini ni v skladu z veljavnimi nacionalnimi prehranskimi smernicami in kot taka predstavlja slabo obvladovan spremenljiv dejavnik tveganja z možnim negativnim vplivom na izide ZTO. Kar 26 udeleženk (37,7 %) je imelo previsok indeks telesne mase (䁥 25 kg/m2), pri čemer ima pomembno vlogo dejstvo, da 33 udeleženk (47,8 %) ne dosega spodnje meje za priporočeno količino telesne dejavnosti s strani Svetovne zdravstvene organizacije. Pomanjkanje vitamina B9 (< 4 ng/ml) je bilo ugotovljeno pri treh ženskah, pomanjkanje vitamina B12 (< 200 pg/ml) pri petih ženskah, kar 44 žensk je bilo nezadostno preskrbljenih z vitaminom D (< 30 ng/ml). Razvidna je potreba po uvedbi prehranske obravnave parov, ki se soočajo z neplodnostjo, kar bi potencialno lahko povečalo ne le uspešnost postopkov ZTO, temveč tudi verjetnost spontane zanositve v nekaterih primerih ter s tem zmanjšala ekonomsko in čustveno breme zdravljenja neplodnosti.

• Language: Slovenian
• Keywords: prehrana, prehranske navade žensk, prehranski vnos, življenjski stil, ženska neplodnost, zdravljenje, zunajtelesna oploditev
• Work type: Master's thesis/paper
• Typology: 2.09 - Master's Thesis
• Organization: BF - Biotechnical Faculty
• Publisher: [L. Trampuš]
• Year: 2024
• PID: 20.500.12556/RUL-154442
• UDC: 613.2-055.2:618.177-089.888.11
• COBISS.SI-ID: 185811459
• Publication date in RUL: 15.02.2024

Secondary language

• Language: English
• Title: Nutritional status of women undergoing in vitro fertilization

Abstract

Better understanding of potential modifiable risk factors with an impact on the success of assisted reproductive technology, such as lifestyle, body composition, dietary habits and micronutrient levels, is needed. Our aim was to examine the status of body composition, nutritional habits, lifestyle and vitamin B9, vitamin B12 and vitamin D levels in women undergoing in vitro fertilization (IVF) in Slovenia. We enrolled 69 volunteers when they visited Gynaecology Clinic, University Medical Centre Ljubljana between January 2023 and March 2023 to start the IVF procedure. Data were obtained by measuring body weight, assessing body composition with a BIA 101 bioimpedance analyser, and a questionnaire on sociodemographic status, dietary habits, frequency of food consumption in the past year, dietary supplement use, smoking experience and physical activity. In addition, a venous blood sample was collected for biochemical laboratory tests (vitamin B9, vitamin B12, vitamin D) at the laboratory of the Clinical Institute of Clinical Chemistry and Biochemistry. The diet of the majority of participants is not in line with Slovenian dietary guidelines and as such represents a poorly controlled modifiable risk factor with a potential negative impact on the outcomes of the IVF. As many as 26 participants (37,7 %) had a body mass index that was too high (䁥 25 kg/m2) and the fact that 33 participants (47,8 %) did not meet the lower limit for the amount of physical activity recommended by the World Health Organization surely plays an important role. Vitamin B9 deficiency (< 4 ng/ml) was found in three women, vitamin B12 deficiency (< 200 pg/ml) in five women, and 44 women had an insufficient level of vitamin D (< 30 ng/ml). These findings highlight the need for nutritional counseling for couples dealing with infertility, which could potentially increase not only the success rate of IVF procedures, but also the likelihood of spontaneous conception in some cases, thereby reducing the economic and emotional burden of infertility treatment.

• Keywords: nutrition, dietary habits of women, dietary intake, lifestyle, female infertility, treatment, in vitro fertilization