Circulating tumor DNA methylation biomarkers for characterization and determination of the cancer origin in malignant liver tumors

Draškovič, Tina (author), Zidar, Nina (author), Hauptman, Nina (author)

Malignant liver tumors include primary malignant liver tumors and liver metastases. They are among the most common malignancies worldwide. The disease has a poor prognosis and poor overall survival, especially with liver metastases. Therefore, early detection and differentiation between malignant liver tumors are critical for patient treatment selection. The detection of cancer and the prediction of its origin is possible with a DNA methylation profile of the tumor DNA compared to that of normal cells, which reflects tissue differentiation and malignant transformation. New technologies enable the characterization of the tumor methylome in circulating tumor DNA (ctDNA), providing a variety of new ctDNA methylation biomarkers, which can provide additional information to clinical decision-making. Our review of the literature provides insight into methylation changes in ctDNA from patients with common malignant liver tumors and can serve as a starting point for further research.

• Language: English
• Keywords: malignant liver tumors, liver metastases, biopsy, primary malignant liver tumors, liquid biopsy, cell-free DNA, circulating tumor DNA, tissue of origin determination, DNA methylation
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: MF - Faculty of Medicine
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 21 str.
• Numbering: Vol. 15, iss. 3, art. 859
• PID: 20.500.12556/RUL-154098
• UDC: 616-006
• ISSN on article: 2072-6694
• DOI: 10.3390/cancers15030859
• COBISS.SI-ID: 142286851
• Publication date in RUL: 25.01.2024

Record is a part of a journal

• Title: Cancers
• Shortened title: Cancers
• Publisher: MDPI
• ISSN: 2072-6694
• COBISS.SI-ID: 517914137

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: maligni tumorji jeter, metastaze v jetrih, biopsija