Molecular structures mediating adhesion of Campylobacter jejuni to abiotic and biotic surfaces

Sabotič, Jerica (author), Janež, Nikolaja (author), Volk, Manca (author), Klančnik, Anja (author)

Microaerophilic, Gram-negative Campylobacter jejuni is the causative agent of campylobacteriosis, the most common bacterial gastrointestinal infection worldwide. Adhesion is the crucial first step in both infection or interaction with the host and biofilm formation, and is a critical factor for bacterial persistence. Here we describe the proteins and other surface structures that promote adhesion to various surfaces, including abiotic surfaces, microorganisms, and animal and human hosts. In addition, we provide insight into the distribution of adhesion proteins among strains from different ecological niches and highlight unexplored proteins involved in C. jejuni adhesion. Protein-protein, protein-glycan, and glycan-glycan interactions are involved in C. jejuni adhesion, with different factors contributing to adhesion to varying degrees under different circumstances. As adhesion is essential for survival and persistence, it represents an interesting target for C. jejuni control. Knowledge of the adhesion process is incomplete, as different molecular and functional aspects have been studied for different structures involved in adhesion. Therefore, it is important to strive for an integration of different approaches to obtain a clearer picture of the adhesion process on different surfaces and to consider the involvement of proteins, glycoconjugates, and polysaccharides and their cooperation.

• Language: English
• Keywords: adhesion, adhesin, Campylobacter, interaction
• Work type: Article
• Typology: 1.02 - Review Article
• Organization: BF - Biotechnical Faculty
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 14 str.
• Numbering: Vol. 287, art. 109918
• PID: 20.500.12556/RUL-153124
• UDC: 579.2
• ISSN on article: 0378-1135
• DOI: 10.1016/j.vetmic.2023.109918
• COBISS.SI-ID: 174177027
• Publication date in RUL: 18.12.2023

Record is a part of a journal

• Title: Veterinary microbiology
• Shortened title: Vet. microbiol.
• Publisher: Elsevier
• ISSN: 0378-1135
• COBISS.SI-ID: 1191700

Licences

• License: CC BY 4.0, Creative Commons Attribution 4.0 International
• Link: http://creativecommons.org/licenses/by/4.0/
• Description: This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

• Language: Slovenian
• Keywords: adhezija bakterij, Campylobacter, adhezini, interakcije