Breast cancer risk prediction using Tyrer-Cuzick algorithm with an 18-SNPs polygenic risk score in a European population with below-average breast cancer incidence

Oblak, Tjaša (author), Škerl, Petra (author), Narang, Benjamin J. (author), Blagus, Rok (author), Krajc, Mateja (author), Novaković, Srdjan (author), Žgajnar, Janez (author)

Goals: To determine whether an 18 single nucleotide polymorphisms (SNPs) polygenic risk score (PRS18) improves breast cancer (BC) risk prediction for women at above-average risk of BC, aged 40–49, in a Central European population with BC incidence below EU average. Methods: 502 women aged 40–49 years at the time of BC diagnosis completed a questionnaire on BC risk factors (as per Tyrer-Cuzick algorithm) with data known at age 40 and before BC diagnosis. Blood samples were collected for DNA isolation. 250 DNA samples from healthy women aged 50 served as a control cohort. 18 BC-associated SNPs were genotyped in both groups and PRS18 was calculated. The predictive power of PRS18 to detect BC was evaluated using a ROC curve. 10-year BC risk was calculated using the Tyrer-Cuzick algorithm adapted to the Slovenian incidence rate (S-IBIS): first based on questionnaire-based risk factors and, second, including PRS18. Results: The AUC for PRS18 was 0.613 (95 % CI 0.570–0.657). 83.3 % of women were classified at above-average risk for BC with S-IBIS without PRS18 and 80.7 % when PRS18 was included. Conclusion: BC risk prediction models and SNPs panels should not be automatically used in clinical practice in different populations without prior population-based validation. In our population the addition of an 18SNPs PRS to questionnaire-based risk factors in the Tyrer-Cuzick algorithm in general did not improve BC risk stratification, however, some improvements were observed at higher BC risk scores and could be valuable in distinguishing women at intermediate and high risk of BC.

• Language: English
• Keywords: early breast cancer, polygenic risk score, risk prediction, Tyrer Cuzick algorithm
• Work type: Article
• Typology: 1.01 - Original Scientific Article
• Organization: MF - Faculty of Medicine; FŠ - Faculty of Sport
• Publication status: Published
• Publication version: Version of Record
• Year: 2023
• Number of pages: 6 str.
• Numbering: Vol. 72, art. 103590
• PID: 20.500.12556/RUL-152893
• UDC: 618.1
• ISSN on article: 0960-9776
• DOI: 10.1016/j.breast.2023.103590
• COBISS.SI-ID: 171467523
• Publication date in RUL: 11.12.2023

Record is a part of a journal

• Title: The Breast
• Shortened title: Breast
• Publisher: Elsevier
• ISSN: 0960-9776
• COBISS.SI-ID: 1316116

Licences

• License: CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
• Link: http://creativecommons.org/licenses/by-nc-nd/4.0/
• Description: The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

• Language: Slovenian
• Keywords: zgodnji rak dojke, poligenski dejavniki tveganja, napoved tveganja

Projects

• Funder: ARRS - Slovenian Research Agency
• Project number: P3-0352
• Name: Družine s povišano ali visoko ogroženostjo za raka: svetovanje, odkrivanje mutacij in preprečevanje raka