Fenofibrate is classified as Class II according to biopharmaceutical classification, indicating
it has good permeability and poor solubility. To enhance its biological availability following
oral administration, dissolution improvement approaches can be employed. In our work, we
prepared solid dispersions in which the carrier of the active ingredient was Syloid 244. We
manufactured solid dispersions with 50 %, 40 %, 30 %, and 20% fenofibrate content and
compared its release. We investigated how the use of different solvents and varying solvent
evaporation temperatures during the preparation of solid dispersions affect their properties.
All solid dispersions were analyzed using differential scanning calorimetry to determine
whether fenofibrate was in an amorphous state. The dispersions were subjected to one-month
aging at a temperature of 40 °C and 75% relative humidity. We performed another analysis
using differential scanning calorimetry and studied the release of fenofibrate from solid
dispersions with 20 % and 30 % fenofibrate content. The solid dispersion with 30%
fenofibrate, prepared in ethyl acetate at 93 °C, exhibited the best properties immediately
after production and after one month of aging. Tablets were compressed from it using Avicel
PH 101 and Syloid 244 as granulating agents
We found that fenofibrate dissolves better from solid dispersions prepared with ethyl acetate
than those prepared with acetone. In solid dispersions prepared at higher temperatures,
fenofibrate deposits more efficiently into the pores of Syloid, leading to fewer changes over
time.
In the experimental work, we decided to prepare one sample of solid dispersions each, as the
results were mostly predictable. Future research will focus on more stable solid dispersions.
To maintain clarity and delve deeper into the analysis, we opted to conduct a limited number
of experiments, so the task does not become overly extensive.
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