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Expected life years compared to the general population
ID Manevski, Damjan (Author), ID Ružić Gorenjec, Nina (Author), ID Kragh Andersen, Per (Author), ID Pohar Perme, Maja (Author)

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Abstract
For cohorts with long-term follow-up, the number of years lost due to a certain disease yields a measure with a simple and appealing interpretation. Recently, an overview of the methodology used for this goal has been published, and two measures have been proposed. In this work, we consider a third option that may be useful in settings in which the other two are inappropriate. In all three measures, the survival of the given dataset is compared to the expected survival in the general population which is calculated using external mortality tables. We thoroughly analyze the differences between the three measures, their assumptions, interpretation, and the corresponding estimators. The first measure is defined in a competing risk setting and assumes an excess hazard compared to the population, while the other two measures also allow estimation for groups that live better than the general population. In this case, the observed survival of the patients is compared to that in the population. The starting point of this comparison depends on whether the entry into the study is a hazard changing event (e.g., disease diagnosis or the age at which the inclusion criteria were met). Focusing on the newly defined life years difference measure, we study the estimation of the variance and consider the possible challenges (e.g., extrapolation) that occur in practice. We illustrate its use with a dataset of French Olympic athletes. Finally, an efficient R implementation has been developed for all three measures which make this work easily available to subsequent users.

Language:English
Keywords:life years lost, survival analysis, statistics, mortality tables, relative survival
Work type:Article
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Publication status:Published
Publication version:Version of Record
Year:2023
Number of pages:17 str.
Numbering:Vol. 65, iss. 4, art. 2200070
PID:20.500.12556/RUL-147380 This link opens in a new window
UDC:311
ISSN on article:1521-4036
DOI:10.1002/bimj.202200070 This link opens in a new window
COBISS.SI-ID:141670403 This link opens in a new window
Publication date in RUL:03.07.2023
Views:439
Downloads:51
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Record is a part of a journal

Title:Biometrical journal
Shortened title:Biom. j.
Publisher:Wiley
ISSN:1521-4036
COBISS.SI-ID:518615833 This link opens in a new window

Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.

Secondary language

Language:Slovenian
Keywords:izgubljena leta življenja, analiza preživetja, statistika

Projects

Funder:ARRS - Slovenian Research Agency
Project number:P3-0154
Name:Metodologija za analizo podatkov v medicini

Funder:ARRS - Slovenian Research Agency
Project number:J3-1761
Name:Število izgubljenih let kot mera bremena bolezni

Funder:ARRS - Slovenian Research Agency
Funding programme:Young researchers

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